Home Chemistry Heterocyclic Building Blocks Other Aliphatic Heterocycles 1,3-Dioxane
Ether Cleavage: 1,3-dioxane can undergo cleavage of the ether linkage to form primary or secondary alcohols. Acidic or basic conditions can be employed for this purpose.
Oxidation: 1,3-dioxane can be oxidized to form compounds with more oxygen-containing functional groups. Common oxidizing agents include potassium permanganate (KMnO4) or hydrogen peroxide (H2O2).
Substitution Reactions: The oxygen atoms in 1,3-dioxane can be substituted with other functional groups through nucleophilic substitution reactions. For example, you can react 1,3-dioxane with alkyl halides or acyl halides to introduce various substituents.
Reduction: 1,3-dioxane can be reduced to form saturated compounds using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Acetal Formation: 1,3-dioxane can be converted into acetals by reacting it with aldehydes or ketones in the presence of acid catalysts. This forms a new cyclic structure.
Grignard Reactions: 1,3-dioxane can react with Grignard reagents to form various products, depending on the specific conditions and reagents used.
Polymerization: Under appropriate conditions, 1,3-dioxane can undergo polymerization to form poly(1,3-dioxane) or related polymers.
Hydrolysis: In the presence of acid or base, 1,3-dioxane can undergo hydrolysis to form diols or other products.
Cleavage Reactions: Cleavage reactions, such as ozonolysis or cleavage with other reagents, can be employed to break down 1,3-dioxane into smaller fragments.
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tert-Butyl (5-formyl-2,2-dimethyl-1,3-dioxan-5-yl)carbamate
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(4R,6R)-tert-Butyl-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate
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tert-butyl 2-((4R,6R)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
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Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate
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Lithium 2,2-dimethyl-1,3-dioxane-5-carboxylate
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5-Ethyl-2,2-dimethyl-1,3-dioxane-5-carboxylic acid
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Diethyl 2,2-dimethyl-1,3-dioxane-5,5-dicarboxylate
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5,5-Bis(bromomethyl)-2,2-dimethyl-1,3-dioxane
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2-(5,5-Dimethyl-1,3-dioxan-2-yl)-2-methylpropan-1-ol
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tert-Butyl 2-((4R,6S)-6-(acetoxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
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