Home Chemistry Heterocyclic Building Blocks Indazoles 7-Nitro-1H-Indazole
Reduction: The nitro group can be reduced to the corresponding amino group under appropriate conditions using reducing agents such as iron, zinc, or tin with hydrochloric acid, or with hydrogen gas over a metal catalyst.
Substitution Reactions: The nitro group can undergo nucleophilic substitution reactions at the ortho or para position with various nucleophiles, such as amines, thiols, or organometallic reagents, to form substituted indazoles.
Diazotization: The amino group can undergo diazotization reactions under acidic conditions to form diazonium salts, which can then be further reacted with various nucleophiles to form substituted products.
Halogenation: The aromatic ring can be halogenated using halogenating agents such as bromine or chlorine, typically in the presence of a Lewis acid catalyst.
Nucleophilic Aromatic Substitution: The indazole ring can undergo nucleophilic aromatic substitution reactions at the C2 or C3 position with appropriate nucleophiles under suitable conditions.
Oxidation: The indazole ring can undergo oxidation reactions at various positions, leading to the formation of oxidized products such as oxindole derivatives.
Reductive Amination: The nitro group can undergo reductive amination reactions to form secondary or tertiary amines under appropriate conditions using reducing agents and amine sources.
Cyclization Reactions: 7-nitro-1H-indazole can participate in cyclization reactions with appropriate reagents to form fused ring systems or heterocyclic compounds.
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