Home Chemistry Organic Building Blocks Bromides 2-Bromo-1-Methyl-4-Nitrobenzene
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—CH3,—NO2).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal 【alkynes|https://www.ambeed.com/alkynyls.html】 using a palladium catalyst, leading to the formation of substituted 【alkynes|https://www.ambeed.com/alkynyls.html】.
Alkylation: Similar to acylation, toluene can also undergo Friedel-Crafts alkylation reactions, where an alkyl group is introduced onto the benzene ring. Alkylation reactions also require a Lewis acid catalyst.
Halogenation: Nitrobenzene can undergo halogenation reactions, where halogen atoms (such as chlorine or bromine) are substituted onto the benzene ring. This is usually achieved using halogenating agents in the presence of a catalyst.
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1-Bromo-4-fluoro-2-methyl-5-nitrobenzene
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2-Bromo-3-fluoro-1-methyl-4-nitrobenzene
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