The NFAT (Nuclear Factor of Activated T cells) family includes members such as NFATc1, NFATc2, NFATc3, NFATc4, and NFAT5. They consist of a phosphorylation-regulated region and a DNA-binding domain, primarily located in the cell nucleus. NFAT is involved in regulating immune responses, cell proliferation, and differentiation, activated through the calcium signaling and calcineurin pathway, allowing them to enter the cell nucleus and promote gene expression. NFAT expression is tissue-specific, and mutations or dysregulation in their gene expression are associated with various diseases, including autoimmune diseases, cardiovascular diseases, and tumors.