Home Chemistry Organic Building Blocks Bromides 2-Bromo-1-Fluoro-4-Methoxybenzene
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—F,—OCH3).
Suzuki-Miyaura Coupling: Bromobenzene can participate in cross-coupling reactions with organoboron compounds in the presence of a palladium catalyst, resulting in the formation of biaryl compounds.
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
Borohydride Demethylation: Methoxybenzene can undergo demethylation reactions using sodium borohydride (NaBH4) in the presence of a proton source, resulting in the formation of phenol.
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4-Bromo-5-fluoro-2-methoxybenzoic acid
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1-Bromo-2-fluoro-5-methoxy-4-nitrobenzene
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4-Bromo-5-fluoro-2-methoxybenzene-1-sulfonyl chloride
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3-Bromo-2,4-difluoro-1,5-dimethoxybenzene
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