Home Chemistry Heterocyclic Building Blocks Pyridines N-(Pyridin-2-Yl)Benzamide
Acylation: N-(pyridin-2-yl)benzamide can undergo acylation reactions, where the amide nitrogen can act as a nucleophile and react with acylating agents (e.g., acid chlorides or anhydrides) to form amide derivatives.
Reductive Amination: The pyridine nitrogen can participate in reductive amination reactions, where it can be converted to secondary or tertiary amines by reacting with appropriate reducing agents and carbonyl compounds.
Grignard Reaction: N-(pyridin-2-yl)benzamide can react with Grignard reagents, which are organomagnesium compounds, to form new carbon-carbon bonds. This reaction can be used to introduce various substituents to the benzene ring.
Substitution Reactions: The benzene ring in N-(pyridin-2-yl)benzamide can undergo electrophilic aromatic substitution reactions, such as nitration, sulfonation, or halogenation, to introduce various functional groups to the aromatic ring.
Reduction: The carbonyl group in the benzamide portion of the molecule can be reduced to form the corresponding amine using reducing agents like LiAlH4 or NaBH4.
Heterocyclic Chemistry: Given the presence of both a benzene ring and a pyridine ring, N-(pyridin-2-yl)benzamide can be used as a starting material for various heterocyclic synthesis reactions.
Coupling Reactions: It can participate in coupling reactions, such as Suzuki coupling or Buchwald-Hartwig amination, to form biaryl or amine derivatives, respectively.
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3-Amino-4-methyl-N-(4-methyl-2-pyridyl)benzamide
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3-(2-Pyridylcarbamoyl)benzeneboronic acid
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Ethyl 3-(4-(methylamino)-3-nitro-N-(pyridin-2-yl)benzamido)propanoate
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Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate
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(4-(Pyridin-2-ylcarbamoyl)phenyl)boronic acid
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(5-Methyl-6-(N-methylbenzamido)pyridin-3-yl)boronic acid
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2-Amino-N-(5-chloropyridin-2-yl)-5-methoxybenzamide
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