Home Chemistry Heterocyclic Building Blocks Piperidines 2-Phenylpiperidine
Electrophilic Aromatic Substitution (EAS): The phenyl ring can undergo typical electrophilic aromatic substitution reactions such as halogenation, nitration, sulfonation, and Friedel-Crafts reactions.
Nucleophilic Substitution: The nitrogen atom in the piperidine ring can undergo nucleophilic substitution reactions. This can involve reactions with alkyl halides or other electrophiles.
Mannich Reaction: 2-Phenylpiperidine can participate in a Mannich reaction, which is a three-component reaction involving an amine, a ketone/aldehyde, and a compound with an acidic proton.
Hofmann Degradation: The piperidine nitrogen can be converted to an amine with the loss of one carbon atom via a Hofmann degradation reaction.
Bromination of the Piperidine Ring: The piperidine ring can be brominated using bromine or a brominating agent.
Hydrogenation: The double bond in the piperidine ring can be hydrogenated to form the corresponding saturated piperidine.
Ring Opening Reactions: Depending on the conditions and reagents used, the piperidine ring can potentially undergo ring-opening reactions.
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1-(tert-Butoxycarbonyl)-6-phenylpiperidine-3-carboxylic acid
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4-(1-(tert-Butoxycarbonyl)piperidin-2-yl)benzoic acid
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2-(3-(Trifluoromethyl)phenyl)piperidine hydrochloride
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2-(2,5-Dimethoxyphenyl)piperidine hydrochloride
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2-(4-Methoxyphenyl)piperidine hydrochloride
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2-(3-Chloro-5-methoxyphenyl)piperidine hydrochloride
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2-(3-Chloro-5-methoxyphenyl)piperidine
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2-(3,5-Dimethylphenyl)piperidine hydrochloride
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