Chemistry Organic Building Blocks Aryls 3-Phenyl-1,2,4,5-Tetrazine

3-Phenyl-1,2,4,5-Tetrazine

Diazo Coupling: The tetrazine ring contains multiple nitrogen atoms, making it capable of reacting with diazonium salts to form azo compounds. For example, you can couple it with an appropriate diazonium salt to introduce a new substituent onto the tetrazine ring. Reduction: 3-Phenyl-1,2,4,5-tetrazine can be reduced to its corresponding dihydrotetrazine using reducing agents like sodium borohydride. This reduction typically occurs at the tetrazine ring, converting the N-N bonds into N-H bonds. Oxidation: It can undergo oxidation reactions to convert it into various oxidation states of the tetrazine ring. Oxidizing agents like hydrogen peroxide or ozone can be used for this purpose. Cycloaddition Reactions: Tetrazines are well-known for their reactivity in inverse electron-demand Diels-Alder reactions with strained alkenes and alkynes, such as cyclooctynes. These reactions are widely used in bioorthogonal chemistry for labeling biomolecules. Halogenation: The phenyl group can be halogenated using appropriate halogenating agents, leading to the introduction of halogen atoms (e.g., Cl, Br) onto the phenyl ring. Nucleophilic Substitution: Depending on the reaction conditions and substituents on the tetrazine ring, nucleophilic substitution reactions can also occur. Nucleophiles can attack the electrophilic positions on the tetrazine ring. Cross-Coupling Reactions: If suitable functional groups are present, 3-phenyl-1,2,4,5-tetrazine can participate in various cross-coupling reactions, such as Suzuki-Miyaura, Stille, or Heck reactions, to form C-C bonds.

Further Reading:

Framework+−

((2S,6S)-6-Phenoxytetrahydro-2H-Pyran-2-Yl)Methanol (2S,4S)-2-Phenoxytetrahydro-2H-Pyran-4-Yl Acetate (6-Phenoxytetrahydro-2H-Pyran-2-Yl)Methanol (8S,9S,14R)-1,2,6,7,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-3H-Cyclopenta[A]Phenanthren-3-One (8S,9S,14R)-7,8,9,11,12,13,14,15,16,17-Decahydro-6H-Cyclopenta[A]Phenanthrene (9H-Fluoren-9-Yl)Methyl (2-(Tritylthio)Ethyl)Carbamate (9H-Fluoren-9-Yl)Methyl Cyclohexylcarbamate (Benzylsulfonyl)Benzene (Cyclopentyloxy)Benzene (E)-1-(2-Hydroxyphenyl)-3-Phenylprop-2-En-1-One (E)-3-Styrylphenol 1,1-Dimethylcyclopropane 1,2-Bis(Diphenylphosphaneyl)Ethane 1,3,4,5-Tetrahydro-2H-Benzo[B]Azepin-2-One 1,3-Diphenylurea 1-(2-Hydroxyphenyl)-2-Phenylethan-1-One 1-(2-Hydroxyphenyl)-3-Phenylprop-2-En-1-One 1-([1,1'-Biphenyl]-4-Yl)Ethan-1-One 1-(Naphthalen-2-Yl)Ethan-1-One 1-Benzyl-4-Chlorobenzene 1-Benzyl-4-Fluorobenzene 1-Bromonaphthalene 1-Chloronaphthalene 1-Fluoronaphthalene 1-Methoxynaphthalene 1-Methyl-4-(Phenylethynyl)Benzene 1-Methylnaphthalene 1-Naphthaldehyde 1-Naphthoic Acid 1-Nitronaphthalene 10H-Phenothiazine 2,2',3,3',5,5',6,6'-Octafluoro-1,1'-Biphenyl 2,5-Diphenylthiophene 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol 2-(Trifluoromethyl)-1,1'-Biphenyl 2-Benzylaniline 2-Bromo-1,1'-Biphenyl 2-Bromonaphthalene 2-Chloro-1,1'-Biphenyl 2-Chloronaphthalene 2-Ethoxynaphthalene 2-Fluorocyclopropane-1-Carboxylic Acid 2-Hydroxycyclohexa-2,5-Diene-1,4-Dione 2-Iodonaphthalene 2-Methoxy-1,1'-Biphenyl 2-Methoxynaphthalene 2-Methoxytetrahydro-2H-Pyran 2-Methyl-1,1'-Biphenyl 2-Methylnaphthalene 2-Naphthaldehyde 2-Naphthoic Acid 2-Naphthonitrile 2-Nitronaphthalene 2-Phenoxytetrahydro-2H-Pyran-4-Yl Acetate 2-Phenylnaphthalene 3,3'-Diphenyl-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthalene 3,3-Diphenyl-3H-Benzo[C][1,2]Oxathiole 1,1-Dioxide 3-Bromo-1,1'-Biphenyl 3-Chloro-1,1'-Biphenyl 3-Fluoro-1,1'-Biphenyl 3-Methyl-1,1'-Biphenyl 3-Methyl-1,1':4',1''-Terphenyl 3-Phenethylphenol 3-Phenyl-1,2,4,5-Tetrazine 3-Styrylphenol 4-(Bromomethyl)-1,1'-Biphenyl 4-(Phenyldiazenyl)Benzoic Acid 4-(Phenylsulfonyl)Morpholine 4-(Tert-Butyl)-1,1'-Biphenyl 4-Cyclohexylphenol 4-Iodo-1,1'-Biphenyl 4-Methoxy-1,1'-Biphenyl 9H-Xanthene [1,1'-Biphenyl]-2-Amine [1,1'-Biphenyl]-2-Carbonitrile [1,1'-Biphenyl]-2-Carboxylic Acid [1,1'-Biphenyl]-2-Ol [1,1'-Biphenyl]-3-Amine [1,1'-Biphenyl]-3-Carbaldehyde [1,1'-Biphenyl]-3-Carboxylic Acid [1,1'-Biphenyl]-3-Ol [1,1'-Biphenyl]-4-Carbaldehyde [1,1'-Biphenyl]-4-Carbonitrile [1,1'-Biphenyl]-4-Ol [1,1'-Biphenyl]-4-Ylboronic Acid Benzyltriphenylphosphonium Cyclopentylbenzene Cyclopropanecarboxylic Acid Cyclopropyl(Phenyl)Methanamine Cyclopropyl(Phenyl)Methanone Diphenyl Phosphonate Diphenylphosphane Diphenylphosphine Oxide Ethane-1,1-Diyldibenzene Ethene-1,1,2-Triyltribenzene Ethyl Cyclopropanecarboxylate Methyl 1-Naphthoate Methyl 2-Naphthoate Methyl [1,1'-Biphenyl]-4-Carboxylate Methyl Cyclopropanecarboxylate N,1-Diphenylmethanimine N,N-Dimethylnaphthalen-1-Amine N-((5R,6R)-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptan-6-Yl)-2-Phenylacetamide N-Benzylbenzamide N-Benzylbenzenesulfonamide N-Cyclopropylbenzamide N-Cyclopropylbenzenesulfonamide N-Phenethylbenzamide N-Phenyl-2-Naphthamide Naphthalen-1-Ol Naphthalen-1-Ylboronic Acid Naphthalen-1-Ylmethanol Naphthalen-2-Amine Naphthalen-2-Ol Naphthalen-2-Ylboronic Acid Naphthalene-1,4-Diol Naphthalene-2-Sulfonic Acid Propane-2,2-Diyldibenzene Tert-Butyl Cyclopropylcarbamate Tetrahydro-2H-Pyran-2-Ol Tetrahydro-2H-Pyran-2-Yl Acetate Tetraphenylmethane Triphenylene Vinylcyclopropane

By Key Group+−

Acetylbenzonitrile Aminobenzyl Benzyl-Imidazole Benzylamine Benzylamino Benzylazanediyl Benzylhydroxylamine Benzylidene Benzylidene Benzyloxazolidine Benzyloxy Benzylpiperazine Benzylpiperidine Benzylthio Benzylthio Cyanobenzyl Dibenzyl Dibenzylamino Dibenzylethane Dibenzylethane Dichlorobenzylidene Difluorobenzyl Dimethoxybenzyl Dimethoxybenzyl Dimethylbenzonitrile Dimethylbenzyl Dimethylbenzyl Dimethylbenzylamine Ethoxybenzyl Ethoxybenzyl Fluorobenzyl Fluorobenzylidene Formylbenzonitrile Iodobenzyl Isopropylbenzonitrile Methoxybenzyl Methoxybenzylamine Methoxybenzylidene Methylbenzonitrile Methylbenzyl Methylbenzyl Methylbenzylamine Methylbenzylidene Methylbenzylidene Nitrobenzyl Nitrobenzylidene Phenoxybenzonitrile Trifluorobenzyl Trifluoromethyl-Benzo Trimethoxybenzyl Trimethoxybenzyl

By Parent Nucleus+−

Acridines Aliphatic Heterocycles Aromatic Heterocycles Azetidines Benzimidazoles Benzisoxazoles Benzofurans Benzothiazoles Benzothiophenes Benzoxazoles Carbazoles Dioxolanes Epoxides Furans Guanidines Imidazoles Imidazolidines Imidazolines Indazoles Indoles Indolines Isoquinolines Isothiazoles Isoxazoles Morpholines Naphthyridines Non-Halogenated Heterocycles Other Aliphatic Heterocycles Other Aromatic Heterocycles Oxadiazoles Oxazoles Oxazolidines Oxazolines Oxetanes Phthalazines Piperazines Piperidines Purines Pyrans Pyrazines Pyrazoles Pyridazines Pyridines Pyrimidines Pyrroles Pyrrolidines Pyrrolines Quinazolines Quinolines Quinoxalines Quinuclidines Spiroes Tetrahydrofurans Tetrahydroisoquinolines Tetrahydropyrans Tetrahydroquinolines Tetrazoles Thiadiazoles Thiazoles Thiazolidines Thiophenols Triazines Triazoles

By Functional Group+−

Acyl Chlorides Alcohols Aldehydes Aliphatic Chain Hydrocarbons Aliphatic Cyclic Hydrocarbons Alkenyls Alkyls Alkynyls Amides Amidines Amines Anhydrides Azoes Benzyl Bromides Benzyl Chlorides Bromides Carboxylic Acid Salts Carboxylic Acids Chiral Building Blocks Chlorides Diazoes Difluoromethyls Esters Ethers Fluorinated Building Blocks Hydrazides Hydrazines Hydrazones Hydroxylamines Iodides Isocyanates and Isothiocyanates Isocyanides Ketones Nitrates and Nitrites Nitriles Nitroes Oximes Phenols Phosphoruses Sulfamides Sulfides Sulfonates Sulfones Sulfonic Acids Sulfonyl Chlorides Sulfonyl Hydrazides Sulfoxides Thioesters Thiols Thiophenes Thioureas Trifluoromethyls Ureas

Carbon related+−

Ar

By Chemical Elements+−

    Bx
    Cx
    Nx
    Ox
    Fx
    Six
    Px
    Sx
    Clx
    Brx
    Ix

    Formula Weight+−

    cLogP+−

    H-Acceptors+−

    H-Donors+−

    Polar Surface Area+−

    Druglikeness+−

    NNCH/NNH+−

    sp3-Atoms+−

    Non-Aromatic Rings+−

    Aromatic Rings+−

    Rotatable Bonds+−

    By Configuration+−

    Typically In Stock
    Purity
    • Please Select
    • 99+%
    • 99%
    • 98+%
    • 98%
    • 97+%
    • 97%
    • 96+%
    • 96%
    • 95+%
    • 95%
    • 93%
    • 90+%
    • 90%
    Size
    • Please Select
    • 1mg
    • 2mg
    • 5mg
    • 10mg
    • 25mg
    • 50mg
    • 100mg
    • 250mg
    • 1g
    • 5g
    • 10g
    • 25g
    • 100g
    • 500g
    • 1000g
    • 1kg
    Clear Filters
    (4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenyl)methanol

    click to sign in and save

    A15021231380500-87-795%

    (4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenyl)methanol

    $552.00/1g

    Detail
    (4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl)methanamine trifluoroacetic acid

    click to sign in and save

    A7219651466420-02-995%

    (4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl)methanamine trifluoroacetic acid

    $75.00/100mg

    Detail
    (4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine hydrochloride

    click to sign in and save

    A2761711416711-59-598%

    (4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine hydrochloride

    $289.00/250mg

    Detail
    3-(4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenoxy)propan-1-amine HCl

    click to sign in and save

    A15158681802908-03-795%

    3-(4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenoxy)propan-1-amine HCl

    $202.00/25mg

    Detail
    4-(6-Methyl-1,2,4,5-tetrazin-3-yl)benzoic acid

    click to sign in and save

    A14435471345866-66-197%

    4-(6-Methyl-1,2,4,5-tetrazin-3-yl)benzoic acid

    $261.00/250mg

    Detail
    Methyltetrazine-acid

    click to sign in and save

    A7573731380500-88-895%

    Methyltetrazine-acid

    $816.00/1g

    Detail
    3-(4-Iodophenyl)-6-methyl-1,2,4,5-tetrazine

    click to sign in and save

    A105841856108-04-495%

    3-(4-Iodophenyl)-6-methyl-1,2,4,5-tetrazine

    $241.00/250mg

    Detail
    4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol

    click to sign in and save

    A122461158884-35-898%

    4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol

    $272.00/250mg

    Detail
    Methyltetrazine-amine HCl

    click to sign in and save

    A11521381596117-29-197%

    Methyltetrazine-amine HCl

    $75.00/100mg

    Detail
    1    page 1 of 1 Pages

    Inquiry