Home Chemistry Heterocyclic Building Blocks Pyridines 3-Iodopyridin-4-Amine
Substitution Reactions: The iodine atom can undergo substitution reactions with various nucleophiles. For instance, it can undergo nucleophilic aromatic substitution reactions, where the iodine atom is replaced by another nucleophile. This can lead to the introduction of different functional groups at the 3-position of the pyridine ring.
Amidation Reactions: The amine group can participate in amidation reactions with carboxylic acids or acyl chlorides to form amides. This reaction typically involves the nucleophilic attack of the amine nitrogen on the electrophilic carbonyl carbon of the carboxylic acid or acyl chloride.
Acylation Reactions: Similar to amidation, the amine group can also undergo acylation reactions with acyl chlorides or acid anhydrides to form amides. This reaction involves the nucleophilic attack of the amine nitrogen on the electrophilic carbonyl carbon of the acyl chloride or acid anhydride.
Reduction Reactions: The iodine atom can be reduced to a lower oxidation state using reducing agents such as lithium aluminum hydride (LiAlH4) or hydrogen gas (H2) in the presence of a catalyst. This can lead to the formation of a substituted pyridine derivative.
Cross-Coupling Reactions: The iodine atom can participate in cross-coupling reactions, such as Suzuki coupling or Stille coupling, to form carbon-carbon bonds with other organic molecules. This reaction typically involves the coupling of the iodine-containing compound with an organometallic reagent or another organic halide.
Functional Group Transformations: Various functional group transformations, such as halogenation, nitration, sulfonation, or oxidation, can be carried out on the 3-iodopyridin-4-amine molecule to introduce different functional groups or modify existing ones.
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5-Iodo-2-(trifluoromethyl)pyridin-4-amine
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