The lipoprotein lipase (LPL) receptor is not traditionally considered a member of the receptor family. LPL primarily localizes to the surface of vascular endothelial cells by interacting with various binding proteins (such as glycoprotein 88, LDL receptor family members) and participates in lipid metabolism, particularly in promoting the hydrolysis of triglyceride-rich lipoproteins (such as VLDL and chylomicrons). This process is crucial for the release of fatty acids and cellular uptake, influencing cardiovascular health, obesity, and metabolic syndrome. Gene-specific expression and mutations in the LPL gene can affect its enzymatic activity, contributing to conditions like hyperlipidemia, insulin resistance, and increased risk of cardiovascular disease.