Home Chemistry Heterocyclic Building Blocks Quinolines 4-Phenylquinoline
Acylation: 4-Phenylquinoline can undergo acylation reactions, where acyl groups (RCO-) are introduced onto the nitrogen atom of the quinoline ring. This is typically achieved by reacting with acyl chlorides or anhydrides in the presence of a base.
Alkylation: Alkylation reactions can be used to introduce alkyl groups onto the nitrogen atom of the quinoline ring. This is typically done using alkyl halides or other alkylating agents.
Reduction: The carbonyl group in 4-phenylquinoline can be reduced to the corresponding alcohol using reducing agents like sodium borohydride (NaBH4) or lithium aluminum hydride (LiAlH4).
Oxidation: The quinoline ring can be oxidized under certain conditions, leading to the formation of various oxidation products.
Substitution Reactions: Various electrophilic aromatic substitution reactions can occur, such as Friedel-Crafts acylation or Friedel-Crafts alkylation, where aromatic ring substitution is achieved. This can lead to the introduction of various functional groups onto the phenyl ring.
Condensation Reactions: 4-Phenylquinoline can participate in condensation reactions to form new compounds. For example, it can undergo Knoevenagel condensation with aldehydes or ketones to form α,β-unsaturated compounds.
Metalation: The nitrogen atom in the quinoline ring can be deprotonated to form a metal quinolinide complex, which can be used as an intermediate in various reactions.
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Ethyl 2-(chloromethyl)-4-phenylquinoline-3-carboxylate hydrochloride
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4-(4-(Trifluoromethyl)phenyl)quinoline
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