The LanC-like protein family is a group of proteins containing LanC domains, primarily involved in the modification and maturation of peptide antibiotics. These proteins typically contain one or more LanC domains, which catalyze cyclization reactions to form thioether bonds. Members of the LanC-like protein family have diverse cellular localization and functions; some are located in the cytoplasm of bacteria, participating in the biosynthesis of antibiotics such as lantibiotics. In eukaryotes, the function and localization of LanC-like proteins are not fully understood. Specific expression and mutations of genes in different species and tissues may lead to changes in antibiotic production and resistance.