The Na+/K+ ATPase is a transmembrane enzyme primarily composed of α (catalytic) and β subunits, existing in multiple isoforms. It is widely distributed on the cell membrane, utilizing ATP to actively transport sodium and potassium ions in and out of the cell, maintaining electrolyte balance and membrane potential. This enzyme is involved in various physiological processes such as neurotransmission, muscle contraction, and cell volume regulation. Specific gene expression and mutations can affect its function, associated with diseases such as hypertension, heart disease, and specific genetic disorders. This enzyme also serves as a target for many drugs, such as cardiac glycosides, which enhance cardiac contractility by inhibiting Na+/K+ ATPase.