Home Chemistry Heterocyclic Building Blocks Piperidines Piperidin-4-Ol
Acid-Base Reactions: Piperidin-4-ol can undergo acid-base reactions due to the presence of the hydroxyl group. It can act as a weak base, accepting a proton from strong acids to form piperidin-4-ol salts.
Oxidation: Piperidin-4-ol can undergo oxidation reactions to form various products, such as piperidin-4-one or other oxidized derivatives. Oxidation can be achieved using oxidizing agents like chromic acid, potassium permanganate, or other mild oxidants.
Esterification: Piperidin-4-ol can react with carboxylic acids in the presence of an acid catalyst to form esters. This reaction is similar to the Fischer esterification reaction commonly observed with alcohols.
Ether Formation: Piperidin-4-ol can undergo ether formation reactions with alkyl halides or alkyl sulfonates in the presence of a base, such as sodium hydride or potassium carbonate, to form piperidin-4-ol ethers.
Nucleophilic Substitution: The hydroxyl group in piperidin-4-ol can act as a nucleophile in substitution reactions with suitable electrophiles. This can include reactions with alkyl halides, acid chlorides, or other suitable electrophilic compounds to form substituted piperidines.
Reduction: Piperidin-4-ol can undergo reduction reactions to form piperidines or other reduced products. Reduction can be achieved using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Condensation Reactions: Piperidin-4-ol can participate in condensation reactions, such as Mannich reactions or aldol condensations, especially if it's derivatized to its corresponding amine or imine forms
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(3R,4S)-tert-Butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate
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(3R,4S)-rel-3-Fluoropiperidin-4-ol hydrochloride
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3,3-Difluoro-1-methylpiperidin-4-ol hydrochloride
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3,3-Difluoro-1-propylpiperidin-4-ol hydrochloride
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tert-Butyl 3,3-difluoro-4-hydroxypiperidine-1-carboxylate
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(R)-tert-Butyl 3,3-difluoro-4-hydroxypiperidine-1-carboxylate
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(S)-tert-Butyl 3,3-difluoro-4-hydroxypiperidine-1-carboxylate
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(3R,4R)-tert-Butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate
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(3S,4S)-tert-Butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate
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tert-Butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate
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cis-tert-Butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate
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(3S,4R)-tert-Butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate
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tert-Butyl trans-3-fluoro-4-hydroxypiperidine-1-carboxylate
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tert-Butyl 4-hydroxy-2-(trifluoromethyl)piperidine-1-carboxylate
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