Home Chemistry Heterocyclic Building Blocks Indoles Tert-Butyl 3-Bromo-1H-Indole-1-Carboxylate
Nucleophilic Substitution Reactions: The bromine atom in the compound is a good leaving group, so tert-butyl 3-bromo-1H-indole-1-carboxylate can undergo nucleophilic substitution reactions. This could involve the replacement of the bromine with a nucleophile (such as an amine or another nucleophilic species), leading to the formation of a substituted product.
Reductive Elimination: Under certain conditions, the compound might undergo reductive elimination reactions, particularly if subjected to reducing agents. This could result in the removal of the bromine atom and the formation of a different product.
Cross-Coupling Reactions: The compound can potentially participate in cross-coupling reactions, such as Suzuki-Miyaura or Stille coupling, where the bromine atom could be replaced by another organic group through the reaction with an appropriate coupling partner.
Ester Hydrolysis: The ester functional group can undergo hydrolysis under acidic or basic conditions, leading to the cleavage of the ester bond and the formation of the corresponding carboxylic acid and alcohol.
Aromatic Substitution: The indole ring may undergo various aromatic substitution reactions, depending on the reaction conditions and the nature of the substituents.
Reduction: The ester moiety can be reduced to the corresponding alcohol, especially under strong reducing conditions.
Cyclization Reactions: Depending on the reaction conditions, the compound may undergo intramolecular cyclization reactions, especially involving the indole ring.
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