Home Chemistry Heterocyclic Building Blocks Pyridines 2,3-Dichloropyridine
Nucleophilic Substitution: Due to the presence of electron-withdrawing chlorine atoms, the pyridine ring is susceptible to nucleophilic substitution reactions. Substitution can occur at either the 2-position, 3-position, or both.
Aromatic Substitution: The pyridine ring can undergo electrophilic aromatic substitution reactions, such as halogenation, nitration, sulfonation, or Friedel-Crafts reactions.
Reduction: The chlorine atoms can be replaced by hydrogen atoms under reducing conditions, such as using metal catalysts like palladium on carbon or hydrogen gas under pressure.
Alkylation/Acylation: The pyridine ring can react with alkyl halides or acyl halides to introduce alkyl or acyl groups onto the ring.
Metalation: The pyridine ring can undergo metalation reactions with strong bases, resulting in the formation of metal complexes.
Oxidation: The compound can undergo oxidation reactions, particularly at the nitrogen atom, to form pyridine-N-oxide derivatives or other oxidized products.
Cross-Coupling Reactions: It can participate in various cross-coupling reactions such as Suzuki, Heck, or Stille reactions when appropriate coupling partners are available.
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2,3-Dichloro-4-methyl-5-(trifluoromethyl)pyridine
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(5,6-Dichloropyridin-3-yl)methanamine hydrochloride
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