Home Chemistry Heterocyclic Building Blocks Indoles 2-(1H-Indol-3-Yl)Acetic Acid
Esterification: The carboxylic acid group can undergo esterification with alcohols to form esters. This reaction is typically catalyzed by acid or acid chlorides.
Amidation: The carboxylic acid group can react with amines to form amides. This reaction can be catalyzed by coupling reagents or activating agents.
Decarboxylation: Under certain conditions, the carboxylic acid group may undergo decarboxylation, resulting in the removal of carbon dioxide and the formation of an indole derivative.
Acid-Base Reactions: The acidic proton in the carboxylic acid group can undergo acid-base reactions with bases to form the corresponding carboxylate ion.
Reduction: The carbonyl group in the carboxylic acid can be reduced to the corresponding alcohol using reducing agents.
Nucleophilic Substitution: The carboxyl group can undergo nucleophilic substitution reactions with nucleophiles, leading to the formation of substituted derivatives.
Indole Ring Reactions: The indole ring can participate in various reactions such as electrophilic aromatic substitution, nucleophilic addition, and other transformations specific to indole derivatives.
Condensation Reactions: The indole ring and carboxylic acid group can participate in condensation reactions, forming heterocyclic compounds or derivatives.
Oxidation: The indole ring or the adjacent carbon atoms can undergo oxidation reactions under certain conditions
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2-(5,6-Difluoro-1H-indol-3-yl)acetic acid
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3-(Carboxymethyl)-1H-indole-2-carboxylic acid
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2-(6-Methoxy-1H-indol-3-yl)acetic acid
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