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Chemical Structure| 130161-46-5 Chemical Structure| 130161-46-5

Structure of 130161-46-5

Chemical Structure| 130161-46-5

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Product Details of [ 130161-46-5 ]

CAS No. :130161-46-5
Formula : C11H8N2O
M.W : 184.19
SMILES Code : O=CC1=CN=C(C2=CC=CC=C2)N=C1
MDL No. :MFCD03085924
InChI Key :AUTGLFSBJLERMV-UHFFFAOYSA-N
Pubchem ID :820135

Safety of [ 130161-46-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H319
Precautionary Statements:P264-P270-P280-P301+P312+P330-P305+P351+P338-P337+P313-P501

Application In Synthesis of [ 130161-46-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 130161-46-5 ]

[ 130161-46-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 38696-20-7 ]
  • [ 107-31-3 ]
  • [ 130161-46-5 ]
YieldReaction ConditionsOperation in experiment
226 mg (34%) With n-butyllithium; In tetrahydrofuran; diethyl ether; REFERENCE EXAMPLE 71 2-Phenyl-5-pyrimidinecarboxyaldehyde To a solution of <strong>[38696-20-7]5-bromo-2-phenylpyrimidine</strong> (850 mg, 3.65 mmol, prepared as described in Org. Lett. 2002, 4, 513) in THF (15 mL) at -100° C. was added dropwise n-BuLi (1.60 mL, 4.00 mmol, 2.5 M solution in hexanes). The reaction mixture was stirred at -100° C. for 15 min, and methyl formate (0.26 mL, 4.20 mmol) was added dropwise. The reaction mixture was stirred for an additional 15 min at -100° C., carefully quenched with a 1 M HCl solution in diethyl ether (4.50 mL, 4.50 mmol), warmed to room temperature, and concentrated in vacuo. The crude reaction mixture was partitioned between dichloromethane and sat. aq. NaHCO3, the organic layer dried with Na2SO4, and concentrated in vacuo. Purification by medium pressure liquid chromatography (SiO2, 4:1 hexanes/ethyl acetate) gave 226 mg (34percent) of the title compound. MS 185 (M+H)+.
 

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