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Chemical Structure| 91421-42-0 Chemical Structure| 91421-42-0

Structure of Rubitecan
CAS No.: 91421-42-0

Chemical Structure| 91421-42-0

Rubitecan

CAS No.: 91421-42-0

Rubitecan is an oraltopoisomerase inhibitor.

Synonyms: RFS 2000; Camptogen; 9-nitro-CPT

4.5 *For Research Use Only !

Cat. No.: A759395 Purity: 98%

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Product Details of Rubitecan

CAS No. :91421-42-0
Formula : C20H15N3O6
M.W : 393.35
SMILES Code : O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C([N+]([O-])=O)C=CC=C5N=C4C3=C2)=O
Synonyms :
RFS 2000; Camptogen; 9-nitro-CPT
MDL No. :MFCD06656294
InChI Key :VHXNKPBCCMUMSW-FQEVSTJZSA-N
Pubchem ID :472335

Safety of Rubitecan

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301
Precautionary Statements:P501-P270-P264-P301+P310+P330-P405
Class:6.1
UN#:1544
Packing Group:

Related Pathways of Rubitecan

DNA

Isoform Comparison

Biological Activity

Description
Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, inducing protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells [1][2][3].

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01833286 Hepatocellular Carcinoma ... More >> Surgery Ablation Less << Phase 3 Not yet recruiting July 2019 China, Guangdong ... More >> Sun Yat-sen University Cancer Center Not yet recruiting Guangzhou, Guangdong, China, 510060 Contact: minshan chen, M.D.    8620-87343117 ext 8620-87343117    chminsh@mail.sysu.edu.cn    Contact: yaojun zhang, M.D.    8620-87343121    zhyaojun@mail.sysu.edu.cn    Principal Investigator: minshan chen, M.D. Less <<
NCT00554905 Hepatocellular Carcinoma ... More >> Liver Cancer Less << Phase 4 Unknown June 2009 China, Guangdong ... More >> Department of Hepatobilliary Surgery, Cancer Center, Sun Yat-sen University Recruiting Guangzhou, Guangdong, China, 510060 Contact: Min-Shan Chen, Doctor    86-20-87343117 ext 86-20-87343117    Chminsh@mail.sysu.edu.cn    Principal Investigator: Min-Shan Chen, Doctor Less <<
NCT02426450 Hepatocellular Carcinoma Phase 2 Unknown April 2017 China, Guangdong ... More >> Zhen-Wei Peng Guangzhou, Guangdong, China, 510080 Less <<
NCT02678013 Hepatocellular Carcinoma Phase 3 Active, not recruiting January 2022 China, Guangdong ... More >> Zhen-Wei Peng Guangzhou, Guangdong, China, 510080 Less <<
NCT01717729 Liver Carcinoma Phase 3 Completed - -
NCT02535117 Hepatocellular Carcinoma Phase 4 Active, not recruiting July 2020 -
NCT00005869 Pancreatic Cancer Phase 3 Unknown - United States, California ... More >> SuperGen, Incorporated Dublin, California, United States, 94568 Less <<
NCT00005871 Pancreatic Cancer Phase 3 Unknown - United States, California ... More >> SuperGen, Incorporated San Ramon, California, United States, 94583 Less <<
NCT02785380 Hepatocellular Carcinoma Phase 4 Not yet recruiting December 2026 -
NCT00006267 Ovarian Cancer ... More >> Primary Peritoneal Cavity Cancer Less << Phase 2 Withdrawn(Never activated.) - -
NCT00005870 Pancreatic Cancer Phase 3 Unknown - United States, California ... More >> SuperGen, Incorporated San Ramon, California, United States, 94583 United States, New York Roswell Park Cancer Institute Buffalo, New York, United States, 14263-0001 Less <<
NCT00006082 Lung Cancer Phase 2 Completed - France ... More >> CRLCC Nantes - Atlantique Nantes-Saint Herblain, France, 44805 Less <<
NCT00006026 Bladder Cancer ... More >> Transitional Cell Cancer of the Renal Pelvis and Ureter Urethral Cancer Less << Phase 2 Completed - Belgium ... More >> U.Z. Gasthuisberg Leuven, Belgium, B-3000 France Centre Jean Perrin Clermont-Ferrand, France, 63011 Centre de Lute Contre le Cancer,Georges-Francois Leclerc Dijon, France, 21079 CRLCC Nantes - Atlantique Nantes-Saint Herblain, France, 44805 Centre Henri Becquerel Rouen, France, 76038 Israel Rambam Medical Center Haifa, Israel, 31096 Italy Azienda Ospedaliera di Padova Padova (Padua), Italy, 35128 Netherlands Rotterdam Cancer Institute Rotterdam, Netherlands, 3075 EA Spain Hospital Universitario 12 de Octubre Madrid, Spain, 28041 Switzerland Ospedale San Giovanni Bellinzona, Switzerland, CH-6500 Clinique De Genolier Genolier, Switzerland, Ch-1272 Less <<
NCT00005826 Brain and Central Nervous Syst... More >>em Tumors Less << Phase 2 Completed - Belgium ... More >> Universitair Ziekenhuis Antwerpen Edegem, Belgium, B-2650 France Centre Jean Perrin Clermont-Ferrand, France, 63011 Centre de Lute Contre le Cancer,Georges-Francois Leclerc Dijon, France, 21079 Centre Leon Berard Lyon, France, 69373 CRLCC Nantes - Atlantique Nantes-Saint Herblain, France, 44805 Centre Eugene Marquis Rennes, France, 35062 Centre Henri Becquerel Rouen, France, 76038 Institut Gustave Roussy Villejuif, France, F-94805 Italy Azienda Ospedaliera di Padova Padua, Italy, 35128 Netherlands Academisch Ziekenhuis der Vrije Universiteit Amsterdam, Netherlands, 1117 MB Spain Hospital Universitario 12 de Octubre Madrid, Spain, 28041 Switzerland Ospedale San Giovanni Bellinzona, Switzerland, CH-6500 Clinique De Genolier Genolier, Switzerland, Ch-1272 Less <<
NCT00250016 - Completed - United States, New Mexico ... More >> University of New Mexico Albuquerque, New Mexico, United States, 87131 Less <<
NCT00250120 Lung Diseases ... More >> Cancer Less << Phase 2 Withdrawn - United States, New Mexico ... More >> University of New Mexico Albuquerque, New Mexico, United States, 87131 Less <<
NCT00006230 Ovarian Cancer Phase 2 Completed - Belgium ... More >> Institut Jules Bordet Brussels, Belgium, B-1000 France Centre Jean Perrin Clermont-Ferrand, France, 63011 Centre de Lutte Contre le Cancer, Georges-Francois Leclerc Dijon, France, 21079 CHU de la Timone Marseille, France, 13385 CRLCC Nantes - Atlantique Nantes-Saint Herblain, France, 44805 Centre Eugene Marquis Rennes, France, 35042 Israel Rabin Medical Center - Beilinson Campus Petah-Tikva, Israel, 49100 Italy Azienda Ospedaliera di Padova Padova (Padua), Italy, 35128 Spain Hospital Universitario 12 de Octubre Madrid, Spain, 28041 Switzerland Ospedale San Giovanni Bellinzona, Switzerland, 6500 Clinique De Genolier Genolier, Switzerland, Ch-1272 United Kingdom Newcastle General Hospital Newcastle Upon Tyne, England, United Kingdom, NE4 6BE Western General Hospital Edinburgh, Scotland, United Kingdom, EH4 2XU Less <<
NCT00113256 Pancreatic Cancer PHASE2|PHASE3 TERMINATED - Compassionate Cancer Care Medi... More >>cal Group, Corona, California, 92882, United States|11100 Warner Avenue, Ste. 200, Fountain Valley, California, 92708, United States|The Cancer Research & Prevention Center, Soquel, California, 95073, United States|Mile High Oncology, Denver, Colorado, 80210, United States|Norton Healthcare, Inc., Louisville, Kentucky, 40202, United States|Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana, 70809, United States|Medical Oncology, Baton Rouge, Louisiana, 70809, United States|N. Mississippi Hematology & Oncology Associates, Tupelo, Mississippi, 38801, United States|Kansas City Cancer Center, Kansas City, Missouri, 64111, United States|Cancer Research of Long Island, Great Neck, New York, 11023, United States|Charleston Hematology Oncology, PA, Charleston, South Carolina, 29403, United States Less <<
NCT00005873 Breast Cancer Phase 2 Completed - United States, California ... More >> SuperGen, Incorporated Dublin, California, United States, 94568 Less <<
NCT00005874 Gastrointestinal Stromal Tumor... More >> Sarcoma Small Intestine Cancer Less << Phase 2 Completed - United States, California ... More >> SuperGen, Incorporated Dublin, California, United States, 94568 Less <<
NCT00005877 Colorectal Cancer Phase 2 Unknown - United States, California ... More >> SuperGen, Incorporated Dublin, California, United States, 94568 Less <<
NCT00005872 Lung Cancer Phase 2 Completed - United States, California ... More >> SuperGen, Incorporated Dublin, California, United States, 94568 Less <<
NCT00006047 Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << Phase 1 Completed - United States, Florida ... More >> H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida, United States, 33612-9497 Less <<
NCT00277082 - Completed - United States, New Mexico ... More >> University of New Mexico Albuquerque, New Mexico, United States, 87131 Less <<
NCT00249990 Corpus Uteri ... More >>Endometrial Cancer Less << Phase 2 Completed - United States, New Mexico ... More >> University of New Mexico Albuquerque, New Mexico, United States, 87131 Less <<
NCT00005875 Melanoma (Skin) Phase 2 Completed - United States, California ... More >> SuperGen, Incorporated Dublin, California, United States, 94568 Less <<
NCT00005820 Prostate Cancer Phase 2 Completed - -
NCT00113113 Tumors PHASE1 COMPLETED - Washington University School o... More >>f Medicine, Saint Louis, Missouri, 63110, United States|The Center for Cancer Care and Research, Saint Louis, Missouri, 63141, United States Less <<
NCT00005876 Esophageal Cancer ... More >> Gastric Cancer Less << Phase 2 Unknown - United States, Texas ... More >> University of Texas - MD Anderson Cancer Center Houston, Texas, United States, 77030-4009 Less <<
NCT00250068 Lung Diseases ... More >> Cancer Less << Phase 2 Completed - United States, New Mexico ... More >> University of New Mexico Albuquerque, New Mexico, United States, 87131 Less <<
NCT00492141 Ewing's Sarcoma Phase 1 Phase 2 Completed - United States, Texas ... More >> U.T.M.D. Anderson Cancer Center Houston, Texas, United States, 77030 Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.54mL

0.51mL

0.25mL

12.71mL

2.54mL

1.27mL

25.42mL

5.08mL

2.54mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

References

 

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