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Chemical Structure| 2288709-96-4 Chemical Structure| 2288709-96-4

Structure of AZ32
CAS No.: 2288709-96-4

Chemical Structure| 2288709-96-4

AZ32

CAS No.: 2288709-96-4

AZ32 is an ATM inhibitor with IC50 <6.2 nM in enzyme assays and 310 nM in cellular assays.

4.5 *For Research Use Only !

Cat. No.: A667472 Purity: 99%

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Product Details of AZ32

CAS No. :2288709-96-4
Formula : C20H16N4O
M.W : 328.37
SMILES Code : O=C(NC)C1=CC=C(C2=CN=C3N2C=C(C4=CC=CC=C4)N=C3)C=C1
MDL No. :MFCD31715431
InChI Key :LCRTUEXVVKVKBD-UHFFFAOYSA-N
Pubchem ID :134814488

Safety of AZ32

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of AZ32

DNA
PI3K-AKT

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
S1-M1-80 cells 1 μM 72 h AZ32 does not alter the protein expression of ABCG2 PMC8173085
Human glioma U87 cells 3 µM 16 h p53 knockdown sensitized U87 cells to AZ32 radiosensitization, resulting in higher rates of mitotic catastrophe. PMC6072596
Human glioma U1242 cells 3 µM 48 h AZ32 and radiation treatment led to increased centrosomes and anaphase bridges, indicating elevated mitotic failure. PMC6072596
Mouse glioma GL261 cells 3 µM 1 h AZ32 blocked the phosphorylation of p53 and KAP-1 post-radiation and sensitized GL261 cells to radiation in a clonogenic survival assay. PMC6072596
DU145 cells 0–100 μM 48 h Evaluate the effect of AZ32 on AR-negative prostate cancer cells, results showed that AZ32 combined with selinexor enhanced apoptosis PMC11774231
LNCaP cells 0–100 μM 48 h Evaluate the effect of AZ32 on prostate cancer cell growth and survival, results showed that AZ32 combined with selinexor enhanced apoptosis and γ-H2AX accumulation PMC11774231

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
C57bl6 mice GL261/luc-red intracranial glioma model Oral 200 mg/kg Once daily for 5 days AZ32 significantly prolonged the survival of mice with intracranial tumors, with more than half of the mice apparently cured compared to radiation alone. PMC6072596

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.05mL

0.61mL

0.30mL

15.23mL

3.05mL

1.52mL

30.45mL

6.09mL

3.05mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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