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Chemical Structure| 623142-96-1 Chemical Structure| 623142-96-1

Structure of Ki20227
CAS No.: 623142-96-1

Chemical Structure| 623142-96-1

Ki20227

CAS No.: 623142-96-1

Ki-20227 is a highly selective c-Fms tyrosine kinase (CSF1R) inhibitor with IC50 value of 2 nM, displaying 6 fold and > 100 fold selectivity over VEGFR2 (IC50=12 nM) and c-Kit/PDGFRβ (IC50=451/217 nM), respectively.

Synonyms: Ki20227

4.5 *For Research Use Only !

Cat. No.: A691021 Purity: 98%

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Product Details of Ki20227

CAS No. :623142-96-1
Formula : C24H24N4O5S
M.W : 480.54
SMILES Code : O=C(NC(C1=NC=CS1)C)NC2=CC=C(OC3=CC=NC4=CC(OC)=C(OC)C=C34)C=C2OC
Synonyms :
Ki20227
MDL No. :MFCD12024693
InChI Key :SHPFDGWALWEPGS-UHFFFAOYSA-N
Pubchem ID :9869779

Safety of Ki20227

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Ki20227

RTK

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.08mL

0.42mL

0.21mL

10.40mL

2.08mL

1.04mL

20.81mL

4.16mL

2.08mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
 

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