1123-63-3|4-Chloro-2,6-dimethylphenol| Ambeed

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Quality Control of [ 1123-63-3 ] Purity: 98% SDS Specification

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Product Details of [ 1123-63-3 ]

CAS No. :	1123-63-3
Formula :	C₈H₉ClO
M.W :	156.61
SMILES Code :	OC1=C(C)C=C(Cl)C=C1C
MDL No. :	MFCD00020138
InChI Key :	VWYKSJIPZHRLNO-UHFFFAOYSA-N
Pubchem ID :	70747

Safety of [ 1123-63-3 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 1123-63-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1123-63-3 ]

[ 1123-63-3 ] Synthesis Path-Downstream 1~35

1
[ 576-26-1 ]
[ 1123-63-3 ]

References: [1]Molecular Crystals and Liquid Crystals (1969-1991),1983,vol. 96,p. 57 - 70.
[2]Angewandte Chemie,1939,vol. 52,p. 263,265.
[3]Journal of the Chemical Society. Perkin transactions I,1977,p. 916 - 923.

2
[ 1123-63-3 ]
[ 109416-34-4 ]

References: [1]Journal of the Chemical Society,1948,p. 209,211.

3
[ 17026-49-2 ]
[ 1123-63-3 ]

References: [1]Journal of Applied Chemistry,1955,vol. 5,p. 289,293.

4
[ 1123-63-3 ]
[ 96-24-2 ]
[ 69557-47-7 ]

References: [1]Journal of the American Chemical Society,1952,vol. 74,p. 1935,1936.

5
[ 1123-63-3 ]
[ 127-00-4 ]
[ 69557-49-9 ]

References: [1]Journal of the American Chemical Society,1952,vol. 74,p. 1935,1936.

6
[ 1123-63-3 ]
[ 546-67-8 ]
[ 95717-55-8 ]

References: [1]Journal of Organic Chemistry,1986,vol. 51,p. 174 - 179.

7
[ 1123-63-3 ]
[ 36433-11-1 ]

References: [1]Australian Journal of Chemistry,1992,vol. 45,p. 337 - 349.

8
[ 1123-63-3 ]
bis(2,6-dimethyl-4-chlorophenyl)phosphoric acid [ No CAS ]

References: [1]Journal of the Indian Chemical Society,1987,vol. 64,p. 60 - 62.
[2]Applied Catalysis A: General,2014,vol. 478,p. 219 - 277.

9
[ 1123-63-3 ]
[ 75-26-3 ]
[ 95729-57-0 ]

References: [1]Journal of Organic Chemistry,1986,vol. 51,p. 174 - 179.

10
[ 101-38-2 ]
[ 1123-63-3 ]
[ 527-61-7 ]
[ 30168-86-6 ]

References: [1]Journal of Organic Chemistry,1994,vol. 59,p. 6543 - 6557.

11
[ 1123-63-3 ]
[ 527-61-7 ]
[ 30168-86-6 ]

References: [1]Journal of Organic Chemistry,1994,vol. 59,p. 6543 - 6557.

12
[ 1123-63-3 ]
[ 77-78-1 ]
[ 14804-27-4 ]

Yield	Reaction Conditions	Operation in experiment
10.45 g	With potassium carbonate; In acetone; for 12.0h;Reflux;	To a suspension of 4-chloro-2,6-dimethylphenol (9) (10 g, 63.8 mmol) and anhydrous potassium carbonate (22 g, 159 mmol) in 250 mL of acetone, dimethyl sulfate (7 mL, 74 mmol) was added under stirring and connected to a reflux system. After spontaneous boiling, the temperature was increased to reflux and kept under these conditions for 8 h. The reaction mixture was cooled to room temperature for addition of more anhydrous potassium carbonate (5 g, 36 mmol) and dimethyl sulfate (4 mL, 42.3 mmol) and returned to reflux for further 4 h. After cooling to room temperature, filtration and evaporation of the filtrate to dryness using a rotary evaporator under vacuum, 10.45 g (96 %) of the 4-chloro-2,6-dimethylphenyl methylether (10) was obtained, which was used directly in the next step without any further purification. GC-MS (70 eV, IE): m/z = 170 [M]+ (67) (cluster of Cl containing [M]+ and [M+2]+), 155 (95), 127 (13), 103 (10), 91 (100).

References: [1]Canadian Journal of Chemistry,1966,vol. 44,p. 2855 - 2866.
[2]Tetrahedron Letters,2013,vol. 54,p. 883 - 886.

13
[ 66074-67-7 ]
[ 1123-63-3 ]
[ 158749-44-1 ]

References: [1]Tetrahedron Letters,1996,vol. 37,p. 8519 - 8522.

14
[ 1123-63-3 ]
[ 73323-91-8 ]
(-)-(R)-2-[2-(4-chloro-2,6-dimethylphenoxy)-1-methylethyl]-1H-isoindole-1,3(2H)-dione [ No CAS ]

References: [1]Tetrahedron Asymmetry,2000,vol. 11,p. 3619 - 3634.
[2]European Journal of Medicinal Chemistry,2013,vol. 65,p. 511 - 516.

15
[ 1123-63-3 ]
[ 70058-19-4 ]
[ 321936-54-3 ]

References: [1]Tetrahedron Asymmetry,2000,vol. 11,p. 3619 - 3634.
[2]European Journal of Medicinal Chemistry,2013,vol. 65,p. 511 - 516.

16
[ 73349-08-3 ]
[ 1123-63-3 ]
(R)-Methyl 2-(4-chloro-2,6-dimethylphenoxy)butanoate [ No CAS ]

References: [1]Il Farmaco,2001,vol. 56,p. 239 - 246.

17
[ 687-47-8 ]
[ 1123-63-3 ]
(R)-Ethyl 2-(4-chloro-2,6-dimethylphenoxy)propanoate [ No CAS ]

References: [1]Il Farmaco,2001,vol. 56,p. 239 - 246.

18
[ 7699-00-5 ]
[ 1123-63-3 ]
(S)-Ethyl 2-(4-chloro-2,6-dimethylphenoxy)propanoate [ No CAS ]

References: [1]Il Farmaco,2001,vol. 56,p. 239 - 246.

19
[ 1123-63-3 ]
[ 73349-07-2 ]
(S)-Methyl 2-(4-chloro-2,6-dimethylphenoxy)butanoate [ No CAS ]

References: [1]Il Farmaco,2001,vol. 56,p. 239 - 246.

20
[ 1123-63-3 ]
[ 116133-09-6 ]
4-((4-chloro-6-(4-chloro-2,6-dimethylphenoxy)-1,3,5-triazin-2-yl)amino)benzonitrile [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2001,vol. 11,p. 2229 - 2234.

21
[ 1123-63-3 ]
[ 20780-54-5 ]
[ 639011-14-6 ]

References: [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5238 - 5248.

22
[ 1123-63-3 ]
[ 20780-53-4 ]
[ 639011-13-5 ]

References: [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5238 - 5248.

23
[ 1123-63-3 ]
[ 576-26-1 ]

References: [1]Chemistry - A European Journal,2005,vol. 11,p. 140 - 151.
[2]Green Chemistry,2009,vol. 11,p. 942 - 945.
[3]Archives of Biochemistry and Biophysics,2011,vol. 505,p. 22 - 32.

24
[ 1123-63-3 ]
[ 527-61-7 ]

References: [1]Chemistry - A European Journal,2005,vol. 11,p. 140 - 151.

25
[ 1123-63-3 ]
[ 762-72-1 ]
[ 576-26-1 ]
[ 13037-83-7 ]

References: [1]Chemistry - A European Journal,2005,vol. 11,p. 140 - 151.

26
[ 1123-63-3 ]
[ 556-52-5 ]
[ 69557-47-7 ]

References: [1]Russian Journal of Organic Chemistry,2002,vol. 38,p. 213 - 219.

27
[ 1123-63-3 ]
(R)-2-(4-chloro-2,6-dimethylphenoxy)-1-phenylethanamine [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5238 - 5248.

28
[ 1123-63-3 ]
(S)-2-(4-chloro-2,6-dimethylphenoxy)-1-phenylethanamine [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5238 - 5248.

29
[ 1123-63-3 ]
[ 639011-23-7 ]

References: [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5238 - 5248.

30
[ 1123-63-3 ]
[ 639011-24-8 ]

References: [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 5238 - 5248.

31
[ 1123-63-3 ]
[ 105905-61-1 ]

References: [1]Il Farmaco,2001,vol. 56,p. 239 - 246.

32
[ 1123-63-3 ]
[ 206363-57-7 ]

References: [1]Il Farmaco,2001,vol. 56,p. 239 - 246.

33
[ 1123-63-3 ]
(R)-2-(4-Chloro-2,6-dimethylphenoxy)propanoic acid [ No CAS ]

References: [1]Il Farmaco,2001,vol. 56,p. 239 - 246.

34
[ 1123-63-3 ]
(S)-2-(4-Chloro-2,6-dimethylphenoxy)propanoic acid [ No CAS ]

References: [1]Il Farmaco,2001,vol. 56,p. 239 - 246.

35
[ 1123-63-3 ]
(R)-2-(4-Chloro-2,6-dimethylphenoxy)butanoic acid [ No CAS ]

References: [1]Il Farmaco,2001,vol. 56,p. 239 - 246.

Historical Records

Technical Information

• Acidity of Phenols • Alkyl Halide Occurrence • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Chan-Lam Coupling Reaction • Electrophilic Substitution of the Phenol Aromatic Ring • Etherification Reaction of Phenolic Hydroxyl Group • Friedel-Crafts Reaction • General Reactivity • Grignard Reaction • Halogenation of Phenols • Hiyama Cross-Coupling Reaction • Hydrogenolysis of Benzyl Ether • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Oxidation of Phenols • Pechmann Coumarin Synthesis • Preparation of Aldehydes and Ketones • Preparation of Alkylbenzene • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reimer-Tiemann Reaction • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Vilsmeier-Haack Reaction

Related Functional Groups of
[ 1123-63-3 ]

Aryls

A226673 [1570-64-5]

4-Chloro-2-methylphenol

Similarity: 1.00

A537650 [52780-67-3]

4,5-Dichloro-2-methylphenol

Similarity: 0.94

A597141 [5306-98-9]

5-Chloro-2-methylphenol

Similarity: 0.93

A831608 [1261911-05-0]

3'-Chloro-3,5'-dimethyl-[1,1'-biphenyl]-4-ol

Similarity: 0.91

Chlorides

A226673 [1570-64-5]

4-Chloro-2-methylphenol

Similarity: 1.00

A537650 [52780-67-3]

4,5-Dichloro-2-methylphenol

Similarity: 0.94

A597141 [5306-98-9]

5-Chloro-2-methylphenol

Similarity: 0.93

A831608 [1261911-05-0]

3'-Chloro-3,5'-dimethyl-[1,1'-biphenyl]-4-ol

Similarity: 0.91

A831608 [1261911-05-0]

3'-Chloro-3,5'-dimethyl-[1,1'-biphenyl]-4-ol

Similarity: 0.91

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P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
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P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
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H200	Unstable explosive
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CAS No.: 1123-63-3

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