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Chemical Structure| 1449-68-9 Chemical Structure| 1449-68-9

Structure of 1449-68-9

Chemical Structure| 1449-68-9

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Product Details of [ 1449-68-9 ]

CAS No. :1449-68-9
Formula : C4H3BrSe
M.W : 209.93
SMILES Code : BrC1=CC=C[Se]1
MDL No. :MFCD20257905

Safety of [ 1449-68-9 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301+H331-H373-H410
Precautionary Statements:P501-P273-P260-P270-P271-P264-P391-P314-P301+P310+P330-P304+P340+P311-P403+P233-P405
Class:6.1
UN#:3440
Packing Group:

Application In Synthesis of [ 1449-68-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1449-68-9 ]

[ 1449-68-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1449-68-9 ]
  • [ 212386-71-5 ]
  • [ 1123312-64-0 ]
YieldReaction ConditionsOperation in experiment
With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In ethanol; water; toluene; for 20h;Reflux; Method B (from 2-bromoselenophene): A mixture of 45.0 g (0.21 mol) of 2-bromoselenophene, 52.0 g (0.26 mol) of <strong>[212386-71-5]4-ethoxy-2,3-difluorophenylboronic acid</strong>, 20.0 g (17.3 mmol) of tetrakis(triphenylphosphine)palladium(0) and 600 ml of 2 N sodium carbonate soln. in 1100 ml of toluene/ethanol (1:1) is heated under reflux for 20 h. After cooling, the organic phase is separated off, and the aqueous phase is extracted with toluene. The combined organic phases are washed with sat. sodium hydrogencarbonate soln., 1 N hydrochloric acid and sat. sodium chloride soln. The solution is dried using sodium sulfate and concentrated to dryness. The residue is purified by column chromatography (SiO2, n-heptane:toluene=3:2). Further purification is carried out by recrystallisation from ethanol; 2-(4-ethoxy-2,3-difluorophenyl)selenophene is obtained as a beige solid.
 

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