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Chemical Structure| 1559-45-1 Chemical Structure| 1559-45-1

Structure of 1559-45-1

Chemical Structure| 1559-45-1

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Product Details of [ 1559-45-1 ]

CAS No. :1559-45-1
Formula : C7H10O2
M.W : 126.15
SMILES Code : O=C1C(C)(C)OC(C)=C1

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Application In Synthesis of [ 1559-45-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1559-45-1 ]

[ 1559-45-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1559-45-1 ]
  • [ 5780-66-5 ]
  • [ 138958-39-1 ]
  • 2
  • [ 1559-45-1 ]
  • 1,8-diazbicyclo[5.4.0]undec-7-ene [ No CAS ]
  • [ 5780-66-5 ]
  • [ 138958-39-1 ]
YieldReaction ConditionsOperation in experiment
In ethanol; EXAMPLE 21 2,2-Dimethyl-5-[2-(2-pyrazinyl)ethenyl]-3(2H)-furanone To a solution of 2,2,5-trimethyl-3(2H)-furanone (2.1 g, 16.7 mM) and pyrazine carboxaldehyde (1.8 g, 16.7 mM) in ethanol (75 mL) was added 1,8-diazbicyclo[5.4.0]undec-7-ene (DBU, 0.26 g, 1.7 mM). The resulting solution was stirred overnight. Then the reaction solution was heated at 60° C. for 4 hours. After the reaction solution was cooled to room temperature, it was diluted with saturated aqueous sodium chloride (200 mL). The aqueous layer was extracted with dichloromethane (3*100 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated under reduced pressure to afford a dark solid. Purification by column chromatography (silica gel, hexane-ethyl acetate) gave a pale yellow solid (1.6 g, 44percent yield). Analytically pure product was obtained by recrystallization from hexane, m.p. 120.5°-121.5° C. Elemental analysis for C12 H12 N2 O2: Calc'd: C, 66.65; H, 5.59; N, 12.95. Found: C, 66.69; H, 5.68; N, 12.81.
 

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