45887-08-9|3-(1H-Pyrazol-3-yl)pyridine| Ambeed

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Quality Control of [ 45887-08-9 ] Purity: 98% SDS Specification

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Product Details of [ 45887-08-9 ]

CAS No. :	45887-08-9
Formula :	C₈H₇N₃
M.W :	145.16
SMILES Code :	C1(C2=NNC=C2)=CC=CN=C1
MDL No. :	MFCD03407951
InChI Key :	JJLMOUMOJSUSSX-UHFFFAOYSA-N
Pubchem ID :	7074967

Safety of [ 45887-08-9 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302
Precautionary Statements:	P280-P305+P351+P338

Application In Synthesis of [ 45887-08-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 45887-08-9 ]

[ 45887-08-9 ] Synthesis Path-Downstream 1~35

1
[ 1028842-93-4 ]
[ 45887-08-9 ]

References: [1]Journal of the Chemical Society,1933,p. 350.

2
3-(pyridin-3-yl)-1H-pyrazole-5-carboxylic acid [ No CAS ]
[ 45887-08-9 ]

References: [1]Journal of the Chemical Society,1933,p. 350.

3
[ 45887-08-9 ]
[ 77-78-1 ]
[ 64091-87-8 ]
[ 176752-73-1 ]

References: [1]Bioorganic and Medicinal Chemistry,1996,vol. 4,p. 227 - 237.
[2]Bioorganic and Medicinal Chemistry,1996,vol. 4,p. 227 - 237.

4
[ 45887-08-9 ]
3-(4-chloro-1H-pyrazol-3-yl)pyridine [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,1996,vol. 4,p. 227 - 237.

5
[ 45887-08-9 ]
[ 148138-02-7 ]

References: [1]Bioorganic and Medicinal Chemistry,1996,vol. 4,p. 227 - 237.

6
[ 45887-08-9 ]
[ 176752-84-4 ]

References: [1]Bioorganic and Medicinal Chemistry,1996,vol. 4,p. 227 - 237.

7
(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one [ No CAS ]
[ 45887-08-9 ]

References: [1]Archiv der Pharmazie,2003,vol. 336,p. 143 - 154.
[2]Dalton Transactions,2005,p. 1910 - 1923.
[3]Bioorganic and Medicinal Chemistry,1996,vol. 4,p. 227 - 237.

9
[ 45887-08-9 ]
[ 75-03-6 ]
3-(1-ethyl-1H-pyrazol-3-yl)pyridine [ No CAS ]
3-(1-ethyl-1H-pyrazol-5-yl)pyridine [ No CAS ]

References: [1]Archiv der Pharmazie,2003,vol. 336,p. 143 - 154.

10
[ 45887-08-9 ]
[ 74-88-4 ]
[ 64091-87-8 ]
[ 176752-73-1 ]

References: [1]Archiv der Pharmazie,2003,vol. 336,p. 143 - 154.

11
[ 1072-63-5 ]
[ 500-22-1 ]
[ 45887-08-9 ]

Yield	Reaction Conditions	Operation in experiment
56%		[0229] 3- (1H-Pyrazol-3-yl) pyridine (27). (See Figure 10. ) To a solution of nicotinaldehyde (2. 0 mL, 21.2 mmol) in 95% EtOH (20 mL) was added 2-tosylhydrazine (3.95 g, 21.2 mmol) and the resultant solution was stirred at room temperature for 2 h. To the solution was added aqueous sodium hydroxide (5 N, 4.2 mL, 21.2 mmol) and the solution was stirred for twenty minutes. To the solution was added 1-vinylimidazole (9.6 mL, 106 mmol) and the resultant solution was warmed to 50 C and stirred under an argon atmosphere for 96 h. The solution was poured into a water/EtOAc mixture (1: 1,100 mL), the organic fraction was collected and the aqueous fraction was extracted with EtOAc (2 x 50 mL). The combined organic fractions were dried (Na2S04), filtered and the solvent was removed in vacuo. The crude material was chromatographed on silica gel (EtOAc/Hex, 50/50, Rf= 0.08) to afford the title compound 27 (1.73 g, 56% yield) as a pale white oil : 1H NMR (CDC13) 8 9.03 (m, 1H), 8.52 (m, 1H), 8.06 (m, 1H), 7.59 (d, J= 2.2 Hz, 1H), 7.29 (m, 1H); 6.61 (d, J= 2.5 Hz, 1H) ; LRMS (ESI) m/z calcd for C8H8N3 [M + H] + 146, found 146.

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 6987 - 7001.
[2]Patent: WO2005/66162,2005,A1 .Location in patent: Page/Page column 61-62.
[3]Journal of Organic Chemistry,2003,vol. 68,p. 5381 - 5383.

12
[ 96-49-1 ]
[ 45887-08-9 ]
[ 401521-85-5 ]

Yield	Reaction Conditions	Operation in experiment
		B] 1-(2-Hydroxyethyl)-3-(3-pyridinyl)-1H-pyrazole was obtained according to example 14B from 1.84 g (12.7 mmol) 3-(3-pyridinyl)-1H-pyrazole and 1.11 g ethylene carbonate. 1.65 g (69%) of the desired product was obtained as a colorless solid. MS (EI): 189.1 (M+). 1H-NMR (DMSO-d6): 3.78 (q, 2H), 4.20 (t, 2H), 4.93 (t, 1H), 6.80 (d, 1H), 7.42 (dd, 1H), 7.80 (d, 1H), 8.13 (m, 1H), 8.49 (dd, 1H), 9.00 (d, 1H).

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 3503 - 3519.
[2]Patent: US2003/199459,2003,A1 .

13
[ 45887-08-9 ]
C₁₆H₁₄BN₆^(1-)*K⁽¹⁺⁾ [ No CAS ]

References: [1]Dalton Transactions,2005,p. 1910 - 1923.

14
[ 45887-08-9 ]
C₂₄H₁₉BN₉^(1-)*K⁽¹⁺⁾ [ No CAS ]

References: [1]Dalton Transactions,2005,p. 1910 - 1923.

15
[ 45887-08-9 ]
C₃₂H₂₄BN₁₂^(1-)*K⁽¹⁺⁾ [ No CAS ]

References: [1]Dalton Transactions,2005,p. 1910 - 1923.

16
[ 903550-35-6 ]
[ 45887-08-9 ]

References: [1]Tetrahedron Letters,2006,vol. 47,p. 4665 - 4669.

17
[ 350-03-8 ]
[ 45887-08-9 ]

References: [1]Dalton Transactions,2005,p. 1910 - 1923.
[2]Bioorganic and Medicinal Chemistry,1996,vol. 4,p. 227 - 237.

18
[ 45887-08-9 ]
[ 401521-88-8 ]