51746-85-1|3-(1H-Imidazol-5-yl)pyridine| Ambeed

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Quality Control of [ 51746-85-1 ] Purity: 98% SDS Specification

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Product Details of [ 51746-85-1 ]

CAS No. :	51746-85-1
Formula :	C₈H₇N₃
M.W :	145.16
SMILES Code :	C1(C2=CNC=N2)=CC=CN=C1
MDL No. :	MFCD10565593
InChI Key :	YFOKBFRTGLSZLU-UHFFFAOYSA-N
Pubchem ID :	3040177

Safety of [ 51746-85-1 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 51746-85-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 51746-85-1 ]

[ 51746-85-1 ] Synthesis Path-Downstream 1~35

1
[ 859076-83-8 ]
[ 51746-85-1 ]

References: [1]Chemische Berichte,1936,vol. 69,p. 1147,1148.
Yakugaku Zasshi,1936,vol. 56,p. 525,528.

2
[ 51746-85-1 ]
3-(1⁽³⁾H-imidazol-4-yl)-piperidine [ No CAS ]

References: [1]Chemische Berichte,1936,vol. 69,p. 1147,1148.
Yakugaku Zasshi,1936,vol. 56,p. 525,528.

3
[ 5394-18-3 ]
[ 51746-85-1 ]
[ 173838-67-0 ]

References: [1]Journal of Asian Natural Products Research,2018,p. 1 - 9.
[2]Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,p. 3075 - 3080.
[3]Patent: US2005/14706,2005,A1 .Location in patent: Page/Page column 8.

5
[ 51746-85-1 ]
[ 251354-75-3 ]
5-methyl-1H-pyrrole-2-carboxylic acid 5-hydroxy-3-methoxy-2,2-dimethyl-6-{8-methyl-2-oxo-4-[2-(4-pyridin-3-yl-imidazol-1-yl)-ethoxy]-2H-chromen-7-yloxy}-tetrahydro-pyran-4-yl ester [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,p. 2875 - 2880.

6
[ 2302-25-2 ]
[ 1692-25-7 ]
[ 51746-85-1 ]

References: [1]Journal of Medicinal Chemistry,2005,vol. 48,p. 224 - 239.

7
[ 96-49-1 ]
[ 51746-85-1 ]
[ 401522-20-1 ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 3503 - 3519.

8
[ 51746-85-1 ]
[ 100-39-0 ]
3-(1-benzyl-1H-imidazol-4-yl)pyridine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
74%		[0338] 3-benzyl-lH-imidazol-4-ylpyridine (60). To a solution of 34 (35 mg, 0.25 mmol) in THF (5 mL) under argon was added sodium hydride (12 mg, 0.29 mmol) in one portion and the resultant slurry was stirred for 20 min. Benzyl bromide (26 uL, 0.32 mmol) was added and the resultant solution was stirred for 10 min. The reaction was quenched by the slow addition of HCl (aq) (1 N, 2 mL), diluted with 13 mL of water and washed with ethyl acetate (3 x 15 ml). Dichloromethane was added (25 mL) and the aqueous fraction was adjusted to pH 9 with NaOH (aq) (10 N). The organic fraction was collected and the aqueous was extracted with dichloromethane (20 mL), the combined organic fractions were dried (Na2S04), filtered and the solvent was removed in vacuo. The crude material was chromatographed on silica gel (CH30H/CHC13, 2.5/97. 5, Rf= 0.26) to afford the title compound 60 (43 mg, 74% yield) as a white semisolid : 1H NMR (CDC13) 8 8.95 (br s, 1H), 8.47 (br s, 1H), 8.10 (m, 1H) 7.64 (m, 1H) 7.42-7. 17 (m, 7H) 5.17 (s, 2H); LRMS (ESI) nilz calcd for C15Hl4N3 [M + H]+ 236, found 236; HRMS (ESI) nilz calcd for C15Hl4N3 [M + H] + 236.1188, found 236.1198 ; HPLC > 99% (tR = 10 min, 60 (A): 40 (B): 0. 02 (C); tR = 6. 12 min, 60 (A): 40 (B): 0. 07 (C)).

References: [1]Journal of Medicinal Chemistry,2005,vol. 48,p. 224 - 239.
[2]Patent: WO2005/66162,2005,A1 .Location in patent: Page/Page column 111.

9
[ 51746-85-1 ]
[ 75-03-6 ]
3-(1-ethyl-1H-imidazol-4-yl)pyridine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
79%		[0337] 3-Ethyl-lH-imidazol-4-yl) pyridine (59). To a solution of 34 (36 mg, 0.25 mmol) in THF (5 mL) under argon was added sodium hydride (12 mg, 0.29 mmol) in one portion and the resultant slurry was stirred for 20 min. Iodoethane (26 pL, 0. 32 mmol) was added and the resultant solution was stirred for 10 min. The reaction was stopped by the careful addition of aqueous hydrochloric acid (1 N, 2 mL), diluted with 13 mL of water and washed with ethyl acetate (3 x 15 ml). Dichloromethane was added (25 mL) and the aqueous was adjusted to pH 9 with NaOH (aq) (10 N). The organic fraction was collected and the aqueous fraction was extracted with dichloromethane (20 mL), the combined organic fractions were dried Na2SO4), filtered and the solvent was removed in vacuo. The crude material was chromatographed on silica gel (CH30H/CHC13, 2.5/97. 5, Rf= 0.27) to afford the title compound 59 (34 mg, 79% yield) as a clear oil :'H NMR (CDCl3) 5 8.93 (m, 1H), 8.44 (m, 1H), 8.07 (m, 1H), 7.54 (br s, 1H), 7.28 (m, 2H), 4.02 (q, J= 7.4 Hz, 2H), 1.49 (t, J= 7.4 Hz, 3H); LRMS (ESI) m/z calcd for GioHnNs [M + H] + 174, found 174; HRMS (ESI) mlz calcd for CloHllN3 [M + H] + 174. 1031, found 174.1042 ; HPLC > 97% (tR = 13. 28 min, 60 (A): 40 (B): 0.02 (C); tR= 3. 67 min, 80 (A): 20 (B): 0. 1 (C).

References: [1]Journal of Medicinal Chemistry,2005,vol. 48,p. 224 - 239.
[2]Patent: WO2005/66162,2005,A1 .Location in patent: Page/Page column 111.

10
[ 51746-85-1 ]
[ 74-88-4 ]
3-(1-methyl-1H-imidazol-4-yl)pyridine [ No CAS ]
[ 859239-29-5 ]

Yield	Reaction Conditions	Operation in experiment
		[0336] 3- (1-Methyl-LH-imidazol-4-yl) pyridine and 3- (1-methyl-1H imidazol-5- yl) pyridine (58a, b). To a solution of 34 (37 mg, 0.26 mmol) in THF (4 mL) under argon was added sodium hydride (11 mg, 0.28 mmol) in one portion and the resultant slurry was stirred for 5 min. Iodomethane (190 pL, 0.31 mmol) was added and the resultant solution was stirred for 10 min. The reaction was stopped by the careful addition of aqueous hydrochloric acid (0.25 N, 6 mL) and washed with ethyl ether (3 x 10 ml). The aqueous fraction was adjusted to pH 9 with NaOH (aq) (10 N) and extracted with ethyl ether (3 x 30 mL), dried (Na2SO4), filtered and the solvent was removed in vacuo. The crude material was chromatographed on silica gel (CH30H/CHCl3, 2.5/97. 5, Rf= 0.15) to afford the title compounds 58a, b as an inseparable mixture (27 mg, 66% yield) of an orange oil: 58a 1H NMR (CDC13) 8 8.95 (m, 1H), 8.47 (m, 1H), 8.11 (m, 1H), 7.52 (br s, 1H), 7.31 (m, 1H), 7.26 (br s, 1H) 3.75 (s, 3H); 58b 1H NMR (CDCl3) 8 8.69 (m, 1H), 8.62 (m, 1H), 7.71 (m, 1H), 7.62 (br s, 1H), 7.39 (m, 1H), 7.19 (br s, 1H), 3.70 (s, 3H); LRMS (ESI) m/z calcd for CgHioNs [M + H] + 160, found 160; HRMS (ESI) m/z calcd forCgHsoN3 [M + H] + 160. 0875, found 160.0866 ; HPLC > 99% (tR = 19.80 min, 55 (A): 45 (B): 0.032 (C); tR = 9.47 min, 55 (A): 45 (B): 0.1 (C).

References: [1]Journal of Medicinal Chemistry,2005,vol. 48,p. 224 - 239.
[2]Patent: WO2005/66162,2005,A1 .Location in patent: Page/Page column 110.

11
[ 5460-29-7 ]
[ 51746-85-1 ]
[ 892860-06-9 ]

References: [1]Bioorganic and Medicinal Chemistry,2006,vol. 14,p. 3697 - 3711.

12
[ 5292-43-3 ]
[ 51746-85-1 ]
[ 568629-89-0 ]

Yield	Reaction Conditions	Operation in experiment
	With NaH; trifluoroacetic acid; In N-methyl-acetamide; dichloromethane; water;	EXAMPLE 90 Preparation of 4-(3-pyridyl)imidazol-1-ylacetic Acid To a solution of 55 mg of 4-(3-pyridyl)imidazole (0.38 mmol, 1.0 eq.) in 2 ml of dry of dimethylformamide was added 15.5 mg of NaH (60%) (0.38 mmol, 1.0 eq.), and the mixture was stirred vigorously for 10 min. before dropwise addition of 0.05 ml of tert-butyl bromoacetate (0.34 mmol, 0.9 eq.). The resulting solution was heated at 70 C. for 30 min before it was diluted with 20 ml of water, and extracted with 3*30 ml of ethyl acetate. The organic extracts were combined and washed sequentially with water, and brine. The organic phase was dried with MgSO4, filtered, and evaporated to give 60 mg of a slight yellow solid. To a solution of above solid in 5 ml of CH2Cl2 was added 5 ml of trifluoroacetic acid, and the resulting solution was stirred at room temperature for 3 h. The solvent was then evaporated under vacuum to give 35 mg of final productproduct.

References: [1]Patent: US6939861,2005,B2 .

13
[ 51746-85-1 ]
[ 325478-13-5 ]

References: [1]Bioorganic and Medicinal Chemistry,2006,vol. 14,p. 3697 - 3711.

14
[ 51746-85-1 ]
C₄₅H₆₈N₆O₁₂ [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2006,vol. 14,p. 3697 - 3711.

15
[ 51746-85-1 ]
C₄₄H₆₆N₆O₁₂ [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2006,vol. 14,p. 3697 - 3711.

16
[ 51746-85-1 ]
[ 892860-49-0 ]

References: [1]Bioorganic and Medicinal Chemistry,2006,vol. 14,p. 3697 - 3711.

17
[ 626-55-1 ]
K₄[Fe(CN)6] [ No CAS ]
[ 51746-85-1 ]

References: [1]Journal of Medicinal Chemistry,2005,vol. 48,p. 224 - 239.

18
[ 51746-85-1 ]
[ 401522-23-4 ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 3503 - 3519.

19
[ 51746-85-1 ]
[ 401522-21-2 ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 3503 - 3519.

20
[ 51746-85-1 ]
[ 401522-22-3 ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 3503 - 3519.

21
[ 51746-85-1 ]
9-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-15-ethyl-8-methoxy-4,6,8,10,12,15a-hexamethyl-3-[2-(4-pyridin-3-yl-imidazol-1-yl)-ethylsulfanyl]-octahydro-1,14-dioxa-cyclopentacyclotetradecene-2,5,11,13-tetraone [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 3503 - 3519.

22
[ 51746-85-1 ]
C₄₄H₆₆N₄O₁₁S [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 3503 - 3519.

23
[ 51746-85-1 ]
C₄₄H₆₄N₄O₁₁S [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 3503 - 3519.

24
[ 51746-85-1 ]
C₆₀H₈₆N₄O₁₆S [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 3503 - 3519.

25
[ 51746-85-1 ]
[ 401522-24-5 ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 3503 - 3519.

26
[ 51746-85-1 ]
[ 191114-48-4 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,p. 3075 - 3080.

27
[ 51746-85-1 ]
[ 173838-63-6 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,p. 3075 - 3080.
[2]Journal of Asian Natural Products Research,2018,p. 1 - 9.

28
[ 857797-77-4 ]
[ 51746-85-1 ]

References: [1]Chemische Berichte,1936,vol. 69,p. 1147,1148.
Yakugaku Zasshi,1936,vol. 56,p. 525,528.

29
[ 857812-29-4 ]
[ 51746-85-1 ]

References: [1]Chemische Berichte,1936,vol. 69,p. 1147,1148.
Yakugaku Zasshi,1936,vol. 56,p. 525,528.

30
[ 107-86-8 ]
[ 51746-85-1 ]
[ 261765-52-0 ]

Yield	Reaction Conditions	Operation in experiment
	With acetic acid; In tetrahydrofuran; for 24h;Heating / reflux;	To a solution of 4-pyridin-3-yl-imidazole (1 g) in THF (34 ML) was added acetic acid (1.6 ML) and 3-methyl-2-butenal (3.3 ML) and the resulting solution was heated under gentle reflux for 24 hours. THF was then removed in vacuo and the residue was purified on a Flash 75 long column eluding with MeOH-CH2Cl2 to give the title compound as slightly yellow oil. MS: m/z 230 (M+H).
	With acetic acid; In tetrahydrofuran;	EXAMPLE 15 3,3-Dimethyl-3(4-Pyridin-3-yl-imidazol-1-yl)-propioaldehyde To a solution of 4-pyridin-3-yl-imidazole (1 g) in THF (34 mL) was added acetic acid (1.6 mL) and 3-methyl-2-butenal (3.3 mL) and the resulting solution was heated under gentle reflux for 24 hours. THF was then removed in vacuo and the residue was purified on a Flash 75 (silica gel column made by Biotage Division of Dyax Corp, U.S.) long column eluding with MeOH-CH2Cl2 to give the title compound as slightly yellow oil. MS: m/z 230 (M+H).
	With acetic acid; In tetrahydrofuran;	Example 15 3,3-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propioaldehyde To a solution of 4-pyridin-3-yl-imidazole (1 g) in THF (34 mL) was added acetic acid (1.6 mL) and 3-methyl-2-butenal (3.3 mL) and the resulting solution was heated under gentle reflux for 24 hours. THF was then removed in vacuoand the residue was purified on a Flash 75 long column eluding with MeOH-CH2Cl2to give the title compound as slightly yellow oil. MS: m/z 230 (M+H).

References: [1]Patent: US6664238,2003,B1 .Location in patent: Page column 26.
[2]Patent: US6420343,2002,B1 .
[3]Patent: EP1298138,2003,A1 .

31
[ 78-85-3 ]
[ 51746-85-1 ]
[ 271795-48-3 ]

Yield	Reaction Conditions	Operation in experiment
	With acetic acid; In tetrahydrofuran; for 48h;Heating / reflux;	2-Methyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propioaldehyde To a solution of 4-pyridin-3-yl-imidazole (8.5 g) in THF (tetrahydrofuran) (293 ML) was added acetic acid (16.8 ML) and methacrolein (9.7 ML) and the resulting solution was heated under gentle reflux for 24 hours.. Another 9.7 ML methacrolein was added and the solution was heated under reflux for another 24 hours. THF was then removed in vacuo and the residue was purified on a Flash 75 long column eluding with MeOH-CH2Cl2 to give the title compound as slightly yellow oil. MS: m/z 215 (M+H).
	With acetic acid; In tetrahydrofuran;	Example 14 2-Methyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propioaldehyde To a solution of 4-pyridin-3-yl-imidazole (8.5 g) in THF (tetrahydrofuran) (293 mL) was added acetic acid (16.8 mL) and methacrolein (9.7 mL) and the resulting solution was heated under gentle reflux for 24 hours. Another 9.7 mL methacrolein was added and the solution was heated under reflux for another 24 hours. THF was then removed in vacuo and the residue was purified on a Flash 75 long column eluding with MeOH-CH2Cl2to give the title compound as slightly yellow oil. MS: m/z 215 (M+H).
	With acetic acid; In tetrahydrofuran;	Example 21 2-Methyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propioaldehyde To a solution of 4-pyridin-3-yl-imidazole (8.5 g) in THF (293 mL) was added acetic acid (16.8 mL) and methacrolein (9.7 mL) and the resulting solution was heated under gentle reflux for 24 hours. Another 9.7 mL methacrolein was added and the solution was heated under reflux for another 24 hours. THF was then removed in vacuoand the residue was purified on a Flash 75 long column eluding with MeOH-CH2Cl2to give the title compound as slightly yellow oil. MS: m/z 215 (M+H).

References: [1]Patent: US6664238,2003,B1 .Location in patent: Page column 26; 28.
[2]Patent: EP1298138,2003,A1 .
[3]Patent: EP1298138,2003,A1 .

32
[ 3492-41-9 ]
[ 51746-85-1 ]
[ 271795-49-4 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium hydroxide; In dimethyl sulfoxide; at 70℃; for 48h;	To a solution of 4-pyridin-3-yl-imidazole (50 mg) in DMSO (methyl sulfoxide) (1.7 ML) was added powered KOH (57 mg) and 3-bromo-2,2-dimethylpropyl acetate and the resulting suspension was heated at 70 C. for 48 hours.. water was added followed by CHCl3, the aqueous layer was extracted with CHCl3, the combined organic layers were washed with brine, dired over Na2SO4 and evaporated in vacuo.. The redisue was purified by preparative TLC (10% MeOH-90% CH2Cl2) the title compound as slightly yellow oil. MS: m/z 274 (M+H).

References: [1]Patent: US6664238,2003,B1 .Location in patent: Page column 26; 28-29.

33
C₂H₂O₄*C₈H₇N₃ [ No CAS ]
[ 51746-85-1 ]

References: [1]Patent: US6353108,2002,B1 .Location in patent: Page column 4.

34
[ 254430-69-8 ]
[ 77287-34-4 ]
[ 51746-85-1 ]

Yield	Reaction Conditions	Operation in experiment
51%	at 20 - 80℃; for 21h;	Stage A2: 4-(3-pyridinyl)-1Himidazole 7.2 g of beta,beta-dimethoxy-3-pyridineethanamine in 15 ml of formamide is heated for 5 hours at 80 C. under nitrogen.. The reaction mixture is maintained under agitation at 20 C. for 16 hours.. In this way the sought product is obtained. (Yield=51%). NMR CDCl3 ppm3.24(s) 3.26(s) 6H 2 CH3O3.55(d, s after exch.) CH2-NHCO3.75(d, s after exch.) CH2-NHCO5.80(m) mobile H

References: [1]Patent: US6353108,2002,B1 .Location in patent: Page column 3-4.

35
[ 51746-85-1 ]
[ 109-64-8 ]
3-[1-(3-bromopropyl)-1H-imidazol-4-yl]-pyridine [ No CAS ]

References: [1]Patent: US2005/14706,2005,A1 .Location in patent: Page/Page column 13.

Historical Records

Technical Information

• Preparation of Amines

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[ 51746-85-1 ]

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P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 51746-85-1

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