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Chemical Structure| 6836-19-7 Chemical Structure| 6836-19-7

Structure of 7-Methoxy-1-tetralone
CAS No.: 6836-19-7

Chemical Structure| 6836-19-7

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Product Citations

Product Citations

Hintzsche, Samuel J. ; Vang, Zoua Pa ; Rivera Torres, Emanuel ; Podoski, Mykaela ; Clark, Joseph R. ;

Abstract: Selective deuterium installation into small molecules is becoming increasingly desirable not only for the elucidation of mechanistic pathways and studying biological processes but also because of deuterium's ability to favorably adjust the pharmacokinetic parameters of bioactive molecules. Fused bicyclic moieties, especially those containing heteroatoms, are prevalent in drug discovery and pharmaceuticals. Herein, we report a copper-catalyzed transfer hydrodeuteration of cyclic and heterocyclic alkenes, which enables the synthesis of chromans, quinolinones, and tetrahydronaphthalenes that are precisely deuterated at the benzylic position. We also demonstrate the ability to place one deuterium atom at the homobenzylic site of these scaffolds with high regioselectivity by swapping transfer reagents for their isotopic analogs. Furthermore, examples of chemoselective transfer hydrogenation and transfer deuteration are disclosed, allowing for the simultaneous incorporation of two vicinal hydrogen or deuterium atoms into a double bond.

Keywords: copper ; deuteration ; hydrodeuteration ; hydrogenation ; transition metal catalysis

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Product Details of 7-Methoxy-1-tetralone

CAS No. :6836-19-7
Formula : C11H12O2
M.W : 176.21
SMILES Code : C1=C(OC)C=CC2=C1C(CCC2)=O
MDL No. :MFCD00001696
InChI Key :GABLTKRIYDNDIN-UHFFFAOYSA-N
Pubchem ID :81276

Safety of 7-Methoxy-1-tetralone

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.68mL

1.14mL

0.57mL

28.38mL

5.68mL

2.84mL

56.75mL

11.35mL

5.68mL

 

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