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Chemical Structure| 74331-70-7 Chemical Structure| 74331-70-7

Structure of 74331-70-7

Chemical Structure| 74331-70-7

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Product Details of [ 74331-70-7 ]

CAS No. :74331-70-7
Formula : C10H10
M.W : 130.19
SMILES Code : CC1=CC=C(C)C(C#C)=C1
MDL No. :N/A

Safety of [ 74331-70-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H318
Precautionary Statements:P210-P280-P305+P351+P338
Class:3
UN#:1993
Packing Group:

Application In Synthesis of [ 74331-70-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 74331-70-7 ]

[ 74331-70-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 626-44-8 ]
  • [ 74331-70-7 ]
  • [ 1335059-32-9 ]
YieldReaction ConditionsOperation in experiment
81% With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine; In tetrahydrofuran; at 40℃; for 16h;Inert atmosphere; A mixture of 3 (210.4 mg, 0.461 mmol), 4 (0.25 mL, 1.75 mmol), PdCl2(PPh3)2 (48.5 mg, 0.069 mmol), PPh3 (36.3 mg, 0.138 mmol), CuI (13.2 mg, 0.069 mmol), Et3N (2.0 mL), and THF (5.0 mL) was placed in a round-bottom flask equipped with a magnetic stirring bar. After degassing the reaction mixture several times, the reaction was carried out at 40 °C for 16 h with stirring. After the reaction mixture was cooled to room temperature, CHCl3 was added to the mixture. Precipitates were removed by filtration, and the solvent was evaporated. The residue was purified by SiO2 column chromatography (hexane as an eluent, Rf = 0.15), and crystallization was carried out to afford 5 as a colorless solid (172.5 mg, 0.373 mmol, 81percent).
  • 2
  • [ 626-44-8 ]
  • [ 74331-70-7 ]
  • [ 1335059-36-3 ]
  • [ 1335059-34-1 ]
  • [ 1335059-32-9 ]
YieldReaction ConditionsOperation in experiment
42%; 32%; 4% With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine; In tetrahydrofuran; at 40℃; for 3h;Inert atmosphere; A mixture of 3 (98.0 mg, 0.211 mmol), 4 (0.06 mL, 0.42 mmol), PdCl2(PPh3)2 (14.8 mg, 0.021 mmol), PPh3 (11.1 mg, 0.042 mmol), CuI (4.0 mg, 0.021 mmol), Et3N (4.0 mL), and THF (5.0 mL) was placed in a round-bottom flask equipped with a magnetic stirring bar. After degassing the reaction mixture several times, the reaction was carried out at 40 °C for 3 h with stirring. After the reaction mixture was cooled to room temperature, CHCl3 was added to the mixture. The mixture was filtered by Celite, and the solvent was evaporated. The residue was subjected to SiO2 column chromatography (hexane as an eluent) to obtain 6 (30.6 mg, 0.067 mmol, 32percent), S1 (40.2 mg, 0.088 mmol, 42percent), and 5 (4.0 mg, 0.086 mmol, 4percent) as colorless solids.
 

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