67247-13-6|7-Methoxynaphthalen-1-ol| Ambeed

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Quality Control of [ 67247-13-6 ] Purity: 98% SDS Specification

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Product Details of [ 67247-13-6 ]

CAS No. :	67247-13-6
Formula :	C₁₁H₁₀O₂
M.W :	174.20
SMILES Code :	COC1=CC=C2C(=C1)C(=CC=C2)O
MDL No. :	MFCD01314215
InChI Key :	KUKJAAZDXZNNPD-UHFFFAOYSA-N
Pubchem ID :	599942

Safety of [ 67247-13-6 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H332-H335
Precautionary Statements:	P261-P280-P305+P351+P338

Application In Synthesis of [ 67247-13-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 67247-13-6 ]

[ 67247-13-6 ] Synthesis Path-Downstream 1~35

1
[ 91142-97-1 ]
[ 67247-13-6 ]

References: [1]Gazzetta Chimica Italiana,1929,vol. 59,p. 854.
[2]Justus Liebigs Annalen der Chemie,1889,vol. 255,p. 293.

2
[ 5302-79-4 ]
[ 67247-13-6 ]

References: [1]Biochemical Journal,1959,vol. 72,p. 344,345.

3
[ 67-56-1 ]
[ 575-38-2 ]
[ 5309-18-2 ]
[ 67247-13-6 ]

References: [1]Australian Journal of Chemistry,1993,vol. 46,p. 731 - 737.

4
[ 5460-29-7 ]
[ 67247-13-6 ]
[ 85926-71-2 ]

References: [1]Analytical Chemistry,1983,vol. 55,p. 1572 - 1575.

5
[ 67247-13-6 ]
[ 29263-68-1 ]
[ 18398-34-0 ]

References: [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1987,vol. 26,p. 668 - 670.

6
[ 19061-33-7 ]
[ 67247-13-6 ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1991,p. 1581 - 1587.

7
[ 575-38-2 ]
[ 77-78-1 ]
[ 67247-13-6 ]
[ 91344-50-2 ]

References: [1]Australian Journal of Chemistry,1993,vol. 46,p. 731 - 737.

8
[ 67247-13-6 ]
[ 106-89-8 ]
1-Chloro-3-(7-methoxy-naphthalen-1-yloxy)-propan-2-ol [ No CAS ]
[ 76275-49-5 ]

References: [1]Journal of Medicinal Chemistry,1981,vol. 24,p. 309 - 314.

9
[ 67247-13-6 ]
[ 75-31-0 ]
[ 106-89-8 ]
[ 76275-53-1 ]

References: [1]Journal of Medicinal Chemistry,1981,vol. 24,p. 309 - 314.

10
[ 358-23-6 ]
[ 67247-13-6 ]
[ 161693-36-3 ]

Yield	Reaction Conditions	Operation in experiment
91%	With 2,6-di-tert-butyl-4-methylpyridine; In dichloromethane; for 12.0h;Reflux;	In a reactor, 2.7 g of 7-methoxy-1-naphthol, 1.1 eq. of triflic anhydride and 1.1 eq. of 2,6-di-tert-butyl-4-methyl-pyridine are introduced into dichloromethane (45 ml). The mixture is heated at reflux for 12 hours and then filtered, and the liquors are washed with 1N HCl solution and then with saturated NaCl solution. The organic phase is evaporated and the residue obtained is purified by chromatography on silica gel (eluant: CH2Cl2/methyl-cyclohexane 1/9) to yield the title product in the form of an oil in a yield of 91% and with a chemical purity of more than 99%.

References: [1]Journal of Organic Chemistry,1995,vol. 60,p. 1265 - 1270.
[2]Patent: US2010/36162,2010,A1 .Location in patent: Page/Page column 2.
[3]Bioorganic and Medicinal Chemistry,2005,vol. 13,p. 89 - 112.

11
[ 85928-57-0 ]
[ 67247-13-6 ]

References: [1]Journal of Organic Chemistry,1995,vol. 60,p. 1265 - 1270.

12
[ 88-88-0 ]
[ 67247-13-6 ]
7-Methoxy-1-(2,4,6-trinitro-phenoxy)-naphthalene [ No CAS ]

References: [1]Russian Journal of Organic Chemistry,1994,vol. 30,p. 295 - 297.
Zhurnal Organicheskoi Khimii,1994,vol. 30,p. 281 - 283.

13
[ 575-38-2 ]
[ 74-88-4 ]
[ 67247-13-6 ]

References: [1]Russian Journal of Organic Chemistry,1994,vol. 30,p. 295 - 297.
Zhurnal Organicheskoi Khimii,1994,vol. 30,p. 281 - 283.

14
[ 67247-13-6 ]
[ 143325-88-6 ]

References: [1]Journal of Medicinal Chemistry,1978,vol. 21,p. 913 - 922.

15
[ 6836-19-7 ]
[ 67247-13-6 ]

References: [1]Tetrahedron,1995,vol. 51,p. 11531 - 11546.
[2]Tetrahedron,1963,vol. 19,p. 1919 - 1937.
[3]Journal of Organic Chemistry,1995,vol. 60,p. 1265 - 1270.
[4]Tetrahedron Asymmetry,2009,vol. 20,p. 467 - 472.

16
[ 67247-13-6 ]
[ 29358-99-4 ]
[ 35152-95-5 ]

References: [1]Journal of medicinal chemistry,1971,vol. 14,p. 1023 - 1026.

17
[ 67247-13-6 ]
[ 53568-05-1 ]

References: [1]Tetrahedron,1995,vol. 51,p. 11531 - 11546.
[2]Tetrahedron Asymmetry,2009,vol. 20,p. 467 - 472.

18
[ 67247-13-6 ]
[ 77-78-1 ]
[ 5309-18-2 ]

References: [1]Tetrahedron,1995,vol. 51,p. 11531 - 11546.

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 3 7-Methoxy-1-naphthalenol Mp 105-107 (a mp of 103-105 is given by A. J. Shand and R. H. Thomson, Tetrahedron, 19, 1919 (1963)). Calcd. for C11 H10 O2: C, 75.84; H, 5.79; Found C, 75.49; H, 5.85, and

21
[ 25109-57-3 ]
[ 67247-13-6 ]
2-acetyl-6'-methoxyspiro[cyclopropane-1,1'(4'H)-naphthalen]-4'-one [ No CAS ]
1-(2,3-dihydro-8-methoxynaphtho[1,2-b]furan-2-yl)ethan-1-one [ No CAS ]

References: [1]Helvetica Chimica Acta,2001,vol. 84,p. 2198 - 2211.

22
[ 4554-16-9 ]
[ 67247-13-6 ]
(Z)-3-[(7-methoxynaphthalen-1-yl)oxy]prop-2-enenitrile [ No CAS ]

References: [1]Helvetica Chimica Acta,2001,vol. 84,p. 2198 - 2211.

23
[ 67247-13-6 ]
[ 3674-13-3 ]
ethyl 8-methoxy-2,3-dihydronaphtho[1,2-b]furan-2-carboxylate [ No CAS ]
ethyl 6'-methoxy-4'-oxospiro[cyclopropane-1,1'(4'H)-naphthalene]-2-carboxylate [ No CAS ]

References: [1]Helvetica Chimica Acta,2001,vol. 84,p. 2198 - 2211.

24
[ 67247-13-6 ]
[ 106-95-6 ]
1-allyloxy-7-methoxy-naphthalene [ No CAS ]

References: [1]Tetrahedron Letters,2006,vol. 47,p. 4051 - 4055.

25
[ 67247-13-6 ]
[ 69739-34-0 ]
[ 960233-24-3 ]

Yield	Reaction Conditions	Operation in experiment
	With 2,6-dimethylpyridine; In dichloromethane; at 0 - 20℃;	To a solution of 25 g 7-methoxy-l-naphthol in 500 mL DCM at 00C was added 26.14 g2,6-diemthylpyridine followed by 45.52 g fer?-butyl(dimethyl)silyl trifluoromethanesulfonate.The mixture was allowed to warm up to room temperature overnight and worked up with water and DCM. The crude product was purified with SGC using hexanes to give the title compound.1H NMR (CDCl3, 500 MHz) delta: 7.73 (d, 8.5 Hz, IH), 7.53 (d, 2.5 Hz, IH)5 7.42 (d, 8.0 Hz, IH)5 7.21 (t, 8.0 Hz5 IH)5 7.16 (dd, 9.0 & 2.5 Hz5 IH), 6.88 (d5 7.5 Hz, IH)5 3.95 (s5 3H)5 1.15 (s5 9H)50.31 (S5 6H).

References: [1]Patent: WO2007/146136,2007,A2 .Location in patent: Page/Page column 22.

26
[ 67247-13-6 ]
[ 107-21-1 ]
[ 959604-19-4 ]

References: [1]Organic Letters,2007,vol. 9,p. 4921 - 4923.

27
[ 67247-13-6 ]
2-allyl-7-methoxy-naphthalen-1-ol [ No CAS ]

References: [1]Tetrahedron Letters,2006,vol. 47,p. 4051 - 4055.

28
[ 67247-13-6 ]
[ 5309-19-3 ]

References: [1]Tetrahedron,1995,vol. 51,p. 11531 - 11546.

29
[ 67247-13-6 ]
[ 161693-40-9 ]

References: [1]Journal of Organic Chemistry,1995,vol. 60,p. 1265 - 1270.
[2]Journal of Organic Chemistry,1995,vol. 60,p. 1265 - 1270.

30
[ 67247-13-6 ]
(S)-1-(Hydroxymethyl)-1-methyl-7-methoxy-1,2-dihydronaphthalene [ No CAS ]

References: [1]Journal of Organic Chemistry,1995,vol. 60,p. 1265 - 1270.
[2]Journal of Organic Chemistry,1995,vol. 60,p. 1265 - 1270.

31
[ 67247-13-6 ]
[ 161693-43-2 ]

References: [1]Journal of Organic Chemistry,1995,vol. 60,p. 1265 - 1270.

32
[ 67247-13-6 ]
(R)-8-Methoxy-2a-methyl-2a,3,4,5-tetrahydro-acenaphthylene [ No CAS ]

References: [1]Journal of Organic Chemistry,1995,vol. 60,p. 1265 - 1270.

33
[ 67247-13-6 ]
(R)-2-(7-methoxy-1-methyl-1,2,3,4-tetrahydronaphthalen-1-yl)acetaldehyde [ No CAS ]

References: [1]Journal of Organic Chemistry,1995,vol. 60,p. 1265 - 1270.

34
[ 67247-13-6 ]
[ 161693-42-1 ]

References: [1]Journal of Organic Chemistry,1995,vol. 60,p. 1265 - 1270.

35
[ 67247-13-6 ]
[ 161693-44-3 ]

References: [1]Journal of Organic Chemistry,1995,vol. 60,p. 1265 - 1270.

Historical Records

Technical Information

• Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Friedel-Crafts Reaction • Hydrogenolysis of Benzyl Ether • Nomenclature of Ethers • Preparation of Alkylbenzene • Preparation of Ethers • Reactions of Benzene and Substituted Benzenes • Reactions of Ethers • Vilsmeier-Haack Reaction

Related Functional Groups of
[ 67247-13-6 ]

Aryls

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1,5-Dimethoxynaphthalene

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(5-Methoxy-2-methylphenyl)methanol

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A225709 [73572-12-0]

[1,1'-Binaphthalen]-2-ol

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A174214 [31574-44-4]

2-Isopropyl-1-methoxy-4-methylbenzene

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Ethers

A178329 [10075-63-5]

1,5-Dimethoxynaphthalene

Similarity: 0.92

A233314 [7417-18-7]

2-(2-Methoxyphenyl)ethanol

Similarity: 0.92

A200464 [73502-04-2]

(5-Methoxy-2-methylphenyl)methanol

Similarity: 0.92

A174214 [31574-44-4]

2-Isopropyl-1-methoxy-4-methylbenzene

Similarity: 0.89

A329636 [5020-41-7]

2-(3-Methoxyphenyl)ethanol

Similarity: 0.89

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CAS No.: 67247-13-6

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